UNC45A - unc-45 myosin chaperone A Gene

Homo sapiens

Also known as OOHE; SMAP1; SMAP-1; GCUNC45; UNC-45A; GC-UNC45; GCUNC-45; IRO039700

Gene ID: 55898 | Gene type: protein coding

About UNC45A

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,930,180-90,954,093 (from NCBI)

This gene has 17 transcripts (splice variants), 199 orthologues, 18 paralogues and is associated with 2 phenotypes. Ubiquitous expression in prostate (RPKM 14.4), skin (RPKM 14.0) and 25 other tissues.

Summary

This gene encodes a regulatory component of the Progesterone Receptor/heat shock protein 90 chaperoning complex, which functions in the assembly and folding of the Progesterone Receptor. The encoded protein is thought to be essential for normal cell proliferation, and for the accumulation of Myosin during development of muscle cells. [provided by RefSeq, Sep 2018]

UNC45A Products(5)

mRNA	Protein	Name
NM_001039675.2	NP_001034764.1	protein unc-45 homolog A isoform 3
NM_001323619.1	NP_001310548.1	protein unc-45 homolog A isoform 2
NM_001323620.2	NP_001310549.1	protein unc-45 homolog A isoform 4
NM_001323621.2	NP_001310550.1	protein unc-45 homolog A isoform 3
NM_018671.5	NP_061141.2	protein unc-45 homolog A isoform 2

UNC45A Protein Structure

TPR_11

TPR_2

UNC45-central

0
200
400
600
800
944 a.a.

Protein Preferred Names

Protein Names

protein unc-45 homolog A

general cell UNC45

Related Diseases

Diseases

Alias

Osteootohepatoenteric Syndrome

OOHE

O2he

Congenital Diarrhea

Inflammatory Bowel Disease 27

IBD27

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Cholestasis

Obstruction Of Bile Duct	Bile Duct Obstruction
Bile Occlusion	Extrahepatic Biliary Obstruction
Extrahepatic Bile Duct Obstruction	Bile Stasis
Biliary Stasis	Obstructive Hyperbilirubinemia
Obstructed Jaundice	Bile Duct Obstructed
Bile Ductal Obstruction	Biliary Duct Obstruction
Obstructed Bile Ductal	Obstructed Biliary Duct
Obstructed Biliary Ductal	Jaundice Regurgitation
Obstructive Jaundice	Cholestatic Jaundice
Cholestatic Jaundice Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15468	UNC45A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UNC45A	RGD	RGD:1305357
Felis catus	UNC45A	VGNC	VGNC:66825
Bos taurus	UNC45A	VGNC	VGNC:36667
Canis familiaris	UNC45A	VGNC	VGNC:48137
Mus musculus	UNC45A	MGD	MGI:2142246
Macaca mulatta	UNC45A	VGNC	VGNC:79858

Name
Email *

	Sorry, but the email address you supplied was invalid.