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  3. DMAP1 - DNA methyltransferase 1 associated protein 1 Gene

DMAP1 - DNA methyltransferase 1 associated protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EAF2; SWC4; MEAF2; DNMAP1; DNMTAP1

Gene ID: 55929 | Gene type: protein coding

About DMAP1

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:44,213,471-44,220,673 (from NCBI)

This gene has 15 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in adrenal (RPKM 14.7), ovary (RPKM 11.2) and 25 other tissues.

Summary

This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA Methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among Others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

DMAP1 Products(3)

mRNA Protein Name
NM_001034023.2 NP_001029195.1 DNA methyltransferase 1-associated protein 1
NM_001034024.2 NP_001029196.1 DNA methyltransferase 1-associated protein 1
NM_019100.5 NP_061973.1 DNA methyltransferase 1-associated protein 1

DMAP1 Protein Structure

DMAP1

DMAP1: DNA methyltransferase 1-associated protein 1 (DMAP1) (243 - 405)

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  • 467 a.a.
Protein Preferred Names Protein Names

DNA methyltransferase 1-associated protein 1

DNMT1 associated protein 1

Related Diseases

Diseases Alias
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant

Autosomal Dominant Cerebellar Ataxia, Deafness And Narcolepsy

ADCADN

Autosomal Dominant Cerebellar Ataxia, Deafness, And Narcolepsy

Adca-Dn Syndrome

Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome

Adca-Dn

Autosomal Dominant Cerebellar Ataxia-Hearing Loss-Narcolepsy Syndrome

Ataxia, Cerebellar, Deafness, And Narcolepsy, Autosomal Dominant
Atrophy Of Testis

Atrophic Testicle

Atrophy Of Testicle

Testicular Atrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03819 DMAP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DMAP1 MGD MGI:1913483
Rattus norvegicus DMAP1 RGD RGD:1311295
Canis familiaris DMAP1 VGNC VGNC:39995
Macaca mulatta DMAP1 VGNC VGNC:71857
Bos taurus DMAP1 VGNC VGNC:59178
Felis catus DMAP1 VGNC VGNC:61524