PPAN - peter pan homolog Gene

Homo sapiens

Also known as SSF; SSF1; SSF2; BXDC3; SSF-1

Gene ID: 56342 | Gene type: protein coding

About PPAN

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,106,223-10,112,012 (from NCBI)

This gene has 8 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in appendix (RPKM 9.7), spleen (RPKM 9.5) and 25 other tissues.

Summary

The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. [provided by RefSeq, Nov 2010]

PPAN Products(3)

mRNA	Protein	Name
NM_001346139.1	NP_001333068.1	suppressor of SWI4 1 homolog isoform 2
NM_001346141.1	NP_001333070.1	suppressor of SWI4 1 homolog isoform 4
NM_020230.7	NP_064615.3	suppressor of SWI4 1 homolog isoform 1

PPAN Protein Structure

Brix

0
100
200
300
400
473 a.a.

Protein Preferred Names

Protein Names

suppressor of SWI4 1 homolog

brix domain-containing protein 3

Related Diseases

Diseases

Alias

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Neurodegeneration With Brain Iron Accumulation 4

NBIA4	Mpan
Mitochondrial Protein-Associated Neurodegeneration	Nbia Due To C19orf12 Mutation
Neurodegeneration With Brain Iron Accumulation Due To C19orf12 Mutation	Neurodegeneration With Brain Iron Accumulation Type 4
Mitochondrial Membrane Protein Associated Neurodegeneration	Neurodegeneration, With Brain Iron Accumulation, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS10916	PPAN Human Pre-designed siRNA Set A	/	Unkown
HY-RS10917	Ppan Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS10918	Ppan Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPAN	MGD	MGI:2178445
Rattus norvegicus	PPAN	RGD	RGD:1306325

Name
Email *

	Sorry, but the email address you supplied was invalid.