2. Gene
  3. CTPS2 - CTP synthase 2 Gene

CTPS2 - CTP synthase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GATD5B

Gene ID: 56474 | Gene type: protein coding

About CTPS2

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:16,587,999-16,712,910 (from NCBI)

This gene has 5 transcripts (splice variants), 133 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 4.6), duodenum (RPKM 4.6) and 25 other tissues.

Summary

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting Enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

CTPS2 Products(3)

mRNA Protein Name
NM_001144002.2 NP_001137474.1 CTP synthase 2
NM_019857.5 NP_062831.3 CTP synthase 2
NM_175859.3 NP_787055.1 CTP synthase 2

CTPS2 Protein Structure

CTP_synth_N

CTP_synth_N: CTP synthase N-terminus (1 - 273)

GATase

GATase: Glutamine amidotransferase class-I (310 - 543)

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  • 586 a.a.
Protein Preferred Names Protein Names

CTP synthase 2

CTP synthase II

Related Diseases

Diseases Alias
Nemaline Myopathy 7

NEM7

Nemaline Myopathy 7, Autosomal Recessive

Cfl2-Related Nemaline Myopathy

Myopathy, Nemaline, Type 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-152149 CTP Synthetase-IN-1 Inhibitor 99.56% Unkown
HY-RS03315 CTPS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CTPS2 RGD RGD:1563369
Felis catus CTPS2 VGNC VGNC:61261
Mus musculus CTPS2 MGD MGI:1933185
Macaca mulatta CTPS2 VGNC VGNC:71550
Bos taurus CTPS2 VGNC VGNC:27809
Canis familiaris CTPS2 VGNC VGNC:39705