2. Gene
  3. DHX33 - DEAH-box helicase 33 Gene

DHX33 - DEAH-box helicase 33 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as DDX33

Gene ID: 56919 | Gene type: protein coding

About DHX33

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:5,440,917-5,468,982 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 5.2), appendix (RPKM 3.8) and 25 other tissues.

Summary

This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

DHX33 Products(2)

mRNA Protein Name
NM_001199699.2 NP_001186628.1 ATP-dependent RNA helicase DHX33 isoform 2
NM_020162.4 NP_064547.2 ATP-dependent RNA helicase DHX33 isoform 1

DHX33 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (86 - 235)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (324 - 408)

HA2

HA2: Helicase associated domain (HA2) (471 - 563)

OB_NTP_bind

OB_NTP_bind: Oligonucleotide/oligosaccharide-binding (OB)-fold (598 - 697)

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  • 707 a.a.
Protein Preferred Names Protein Names

ATP-dependent RNA helicase DHX33

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 33

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-156418 KY386 Inhibitor 99.01% Unkown
HY-RS03752 DHX33 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DHX33 MGD MGI:2445102
Felis catus DHX33 VGNC VGNC:61478
Macaca mulatta DHX33 VGNC VGNC:71633
Canis familiaris DHX33 VGNC VGNC:39943
Bos taurus DHX33 VGNC VGNC:54418
Rattus norvegicus DHX33 RGD RGD:1307239