LXN - latexin Gene

Homo sapiens

Also known as ECI; TCI

Gene ID: 56925 | Gene type: protein coding

About LXN

Cytogenetic location: 3q25.32 Genomic coordinates (GRCh38): 3:158,666,414-158,672,648 (from NCBI)

This gene has 2 transcripts (splice variants), 191 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 17.1), gall bladder (RPKM 15.4) and 24 other tissues.

Summary

This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. The encoded protein, latexin, downregulates the population size of hematopoietic stem cells. This protein is found to be downregulated in Cancer cells because of promoter hypermethylation. [provided by RefSeq, Jul 2020]

LXN Products(1)

mRNA	Protein	Name
NM_020169.4	NP_064554.3	latexin

LXN Protein Structure

Latexin

0
100
200
222 a.a.

Protein Preferred Names

Protein Names

latexin

MUM

Recombinant LXN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73841	Latexin Protein, Human (His)	Q9BS40/NP_064554.3 (E2-E222)	≥95%
HY-P73842	Latexin Protein, Human (HEK293, Fc)	Q9BS40 (E2-E222)	≥95%

Related Diseases

Diseases

Alias

Lissencephaly 7 With Cerebellar Hypoplasia

LIS7	Lissencephaly 7, With Cerebellar Hypoplasia
Lissencephaly, Type 7, With Cerebellar Hypoplasia

Lissencephaly 8

LIS8

Encephalitozoonosis

Infection By Encephalitozoon

Amyloidosis, Familial Visceral

Ostertag Type Amyloidosis	German Type Amyloidosis
Familial Renal Amyloidosis	Amyloidosis Viii
Amyloidosis, 3 Or More Types	Familial Visceral Amyloidosis
Familial Amyloid Nephropathy	Hereditary Amyloid Nephropathy
Amyloidosis, Familial Renal	Amyloidosis, Systemic Nonneuropathic
Amyloidosis Familial Visceral	Amyloidosis 8
Amyloidosis, Ostertag Type	Hereditary Amyloidosis With Primary Renal Involvement
Hereditary Renal Amyloidosis	Renal Amyloidosis
Amyloidosis, Renal	Systemic Nonneuropathic Amyloidosis
Amyloidosis Familial Renal	Amyloidosis Systemic Nonneuropathic
Hereditary Amyloidosis With Primary Renal Involement	AMYL8
Systemic Non-Neuropathic Amyloidosis	Amyloid Nephropathy

Comedo Carcinoma

Comedocarcinoma

High Grade Ductal Breast Carcinoma In Situ

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07895	LXN Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LXN	VGNC	VGNC:63332
Rattus norvegicus	LXN	RGD	RGD:68361
Mus musculus	LXN	MGD	MGI:107633
Macaca mulatta	LXN	VGNC	VGNC:74279
Bos taurus	LXN	VGNC	VGNC:31087
Canis familiaris	LXN	VGNC	VGNC:42871
Others	LXN	NCBI