CYSLTR2 - cysteinyl leukotriene receptor 2 Gene

Homo sapiens

Also known as HG57; CYSLT2; GPCR21; HPN321; CYSLT2R; KPG_011; hGPCR21; PSEC0146

Gene ID: 57105 | Gene type: protein coding

About CYSLTR2

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:48,653,929-48,711,226 (from NCBI)

This gene has 6 transcripts (splice variants), 80 orthologues, 16 paralogues and is associated with 53 phenotypes. Broad expression in placenta (RPKM 7.8), heart (RPKM 2.8) and 17 other tissues.

Summary

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]

CYSLTR2 Products(11)

mRNA	Protein	Name
NM_001308476.3	NP_001295405.1	cysteinyl leukotriene receptor 2
NM_020377.5	NP_065110.1	cysteinyl leukotriene receptor 2
NM_001387013.1	NP_001373942.1	cysteinyl leukotriene receptor 2
NM_001308465.3	NP_001295394.1	cysteinyl leukotriene receptor 2
NM_001308468.3	NP_001295397.1	cysteinyl leukotriene receptor 2
NM_001308467.3	NP_001295396.1	cysteinyl leukotriene receptor 2
NM_001387014.1	NP_001373943.1	cysteinyl leukotriene receptor 2
NM_001308469.3	NP_001295398.1	cysteinyl leukotriene receptor 2
NM_001308471.3	NP_001295400.1	cysteinyl leukotriene receptor 2
NM_001308470.3	NP_001295399.1	cysteinyl leukotriene receptor 2
NM_001387012.1	NP_001373941.1	cysteinyl leukotriene receptor 2

CYSLTR2 Protein Structure

7tm_1

0
100
200
300
346 a.a.

Protein Preferred Names

Protein Names

cysteinyl leukotriene receptor 2

G-protein coupled receptor GPCR21	G-protein coupled receptor HG57
cysteinyl leukotriene CysLT2 receptor

Related Diseases

Diseases

Alias

Conjunctival Cancer

Malignant Neoplasm Of Conjunctiva	Conjunctival Neoplasms
Conjunctival Tumor	Malignant Conjunctival Tumor
Malignant Tumor Of Conjunctiva	Neoplasm Of Conjunctiva
Conjunctiva Cancer	Primary Malignant Neoplasm Of Conjunctiva

Melanoma, Uveal

Uveal Melanoma	Choroidal Melanoma
Melanoma Of Uvea	Iris Melanoma
Malignant Melanoma Of Choroid	Malignant Melanoma Of Iris

Malignant Conjunctival Melanoma

Conjunctival Melanoma	Malignant Melanoma Of Conjunctiva
Conjunctival Malignant Melanoma

Vernal Conjunctivitis

Conjunctivitis Vernal

Conjunctivitis, Vernal

Asthma, Nasal Polyps, And Aspirin Intolerance

Asthma And Nasal Polyps	Asa Triad
Asthma, Aspirin-Induced, Susceptibility To	Asthma, Aspirin-Induced
Asthma, With Nasal Polyps And Aspirin Intolerance	ANPAI
Aia	Aspirin-Intolerant Asthma
Asthma Aspirin-Induced	Nasal Polyps Asthma And Aspirin Sensitivity
Samter Triad	Asthma With Aspirin Triad Including Nonsteroidal Anti-Inflammatory Activity And Nasal Polyps

Aspirin-Induced Respiratory Disease

Aspirin-Sensitive Asthma

Persistent Mild Asthma

Exercise-Induced Bronchoconstriction

Exercise-Induced Asthma

Asthma Exercise-Induced

Ocular Melanoma

Intraocular Melanoma	Uveal Melanoma
Eye Melanoma	Melanoma Of Eye
Melanoma Of The Uvea	Malignant Melanoma Of Eye

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Uveal Disease

Uveal Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03497	CYSLTR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03498	Cysltr2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03499	Cysltr2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CYSLTR2	MGD	MGI:1917336
Bos taurus	CYSLTR2	VGNC	VGNC:50271
Macaca mulatta	CYSLTR2	VGNC	VGNC:106256
Rattus norvegicus	CYSLTR2	RGD	RGD:619797
Canis familiaris	CYSLTR2	VGNC	VGNC:57504

Name
Email *

	Sorry, but the email address you supplied was invalid.