TMEM63C - transmembrane protein 63C Gene

Homo sapiens

Also known as CSC1; SPG87; hsCSC1; C14orf171

Gene ID: 57156 | Gene type: protein coding

About TMEM63C

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:77,181,798-77,259,495 (from NCBI)

This gene has 8 transcripts (splice variants), 201 orthologues and 2 paralogues. Biased expression in brain (RPKM 4.3), testis (RPKM 3.7) and 13 other tissues.

Summary

Enables calcium activated cation channel activity. Involved in cation transport. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Biomarker of focal segmental glomerulosclerosis. [provided by Alliance of Genome Resources, Apr 2022]

TMEM63C Products(1)

mRNA	Protein	Name
NM_020431.4	NP_065164.2	calcium permeable stress-gated cation channel 1

TMEM63C Protein Structure

RSN1_TM

PHM7_cyt

RSN1_7TM

0
200
400
600
806 a.a.

Protein Preferred Names

Protein Names

calcium permeable stress-gated cation channel 1

calcium permeable stress-gated cation channel 1 homolog

Related Diseases

Diseases

Alias

Spastic Paraplegia 87, Autosomal Recessive

SPG87

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Coffin-Siris Syndrome 3

CSS3	Mrd15
Mental Retardation, Autosomal Dominant 15	Autosomal Dominant Mental Retardation 15
Coffin-Siris Syndrome, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14734	TMEM63C Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TMEM63C	VGNC	VGNC:66357
Rattus norvegicus	TMEM63C	RGD	RGD:1310207
Canis familiaris	TMEM63C	VGNC	VGNC:47597
Mus musculus	TMEM63C	MGD	MGI:2444386
Bos taurus	TMEM63C	VGNC	VGNC:36105
Macaca mulatta	TMEM63C	VGNC	VGNC:79411

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