2. Gene
  3. CLK4 - CDC like kinase 4 Gene

CLK4 - CDC like kinase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 57396 | Gene type: protein coding

About CLK4

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:178,602,664-178,627,050 (from NCBI)

This gene has 13 transcripts (splice variants), 625 orthologues and 12 paralogues. Ubiquitous expression in lymph node (RPKM 15.9), bone marrow (RPKM 13.8) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]

CLK4 Products(1)

mRNA Protein Name
NM_020666.3 NP_065717.1 dual specificity protein kinase CLK4

CLK4 Protein Structure

Pkinase

Pkinase: Protein kinase domain (159 - 475)

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  • 481 a.a.
Protein Preferred Names Protein Names

dual specificity protein kinase CLK4

protein serine threonine kinase Clk4

Related Diseases

Diseases Alias
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15338 TG003 Inhibitor 99.55% Unkown
HY-112296 T025 98.84% Unkown
HY-15951 ML167 Inhibitor 98.62% Unkown
HY-111379 EHT 5372 Inhibitor 98.12% Unkown
HY-123600 SRI-29329 Inhibitor 99.73% Unkown
HY-12828A KH-CB20 Inhibitor 99.80% Unkown
HY-149262 CLK1-IN-3 98.03% Unkown
HY-131978 DB18 Inhibitor 98.27% Unkown
HY-125202 KuWal151 Inhibitor / Unkown
HY-146335 CLK1/4-IN-1 Inhibitor / Unkown
HY-15338A (E/Z)-TG003 Inhibitor / Unkown
HY-155723 Leucettinib-92 Inhibitor / Unkown
HY-RS02819 CLK4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CLK4 VGNC VGNC:27451
Canis familiaris CLK4 VGNC VGNC:39349
Macaca mulatta CLK4 VGNC VGNC:71173
Felis catus CLK4 VGNC VGNC:60965
Rattus norvegicus CLK4 RGD RGD:1310274
Mus musculus CLK4 MGD MGI:1098551