SPC25 - SPC25 component of NDC80 kinetochore complex Gene

Homo sapiens

Also known as AD024; SPBC25; hSpc25

Gene ID: 57405 | Gene type: protein coding

About SPC25

Cytogenetic location: 2q24.3 Genomic coordinates (GRCh38): 2:168,861,521-168,890,430 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele and 199 orthologues. Broad expression in lymph node (RPKM 4.1), bone marrow (RPKM 2.8) and 19 other tissues.

Summary

This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008]

SPC25 Products(1)

mRNA	Protein	Name
NM_020675.4	NP_065726.1	kinetochore protein Spc25

SPC25 Protein Structure

Spindle_Spc25

0
100
200
224 a.a.

Protein Preferred Names

Protein Names

kinetochore protein Spc25

2600017H08Rik

Related Diseases

Diseases

Alias

Diffuse Idiopathic Skeletal Hyperostosis

Hyperostosis, Diffuse Idiopathic Skeletal	Ankylosing Vertebral Hyperostosis
Dish	Disseminated Idiopathic Skeletal Hyperostosis
Forestier Disease	Forestier'S Disease
Hyperostosis Diffuse Idiopathic Skeletal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13648	SPC25 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SPC25	RGD	RGD:1307811
Felis catus	SPC25	VGNC	VGNC:65625
Bos taurus	SPC25	VGNC	VGNC:35196
Mus musculus	SPC25	MGD	MGI:1913692
Canis familiaris	SPC25	VGNC	VGNC:46724
Macaca mulatta	SPC25	VGNC	VGNC:104556

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