2. Gene
  3. CNOT6 - CCR4-NOT transcription complex subunit 6 Gene

CNOT6 - CCR4-NOT transcription complex subunit 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CCR4; Ccr4a

Gene ID: 57472 | Gene type: protein coding

About CNOT6

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:180,494,379-180,578,358 (from NCBI)

This gene has 7 transcripts (splice variants), 235 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 8.0), urinary bladder (RPKM 6.4) and 25 other tissues.

Summary

This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]

CNOT6 Products(3)

mRNA Protein Name
NM_001370472.1 NP_001357401.1 CCR4-NOT transcription complex subunit 6 isoform 1
NM_001370473.1 NP_001357402.1 CCR4-NOT transcription complex subunit 6 isoform 2
NM_001370474.1 NP_001357403.1 CCR4-NOT transcription complex subunit 6 isoform 3

CNOT6 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (51 - 109)

Exo_endo_phos

Exo_endo_phos: Endonuclease/Exonuclease/phosphatase family (192 - 531)

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  • 557 a.a.
Protein Preferred Names Protein Names

CCR4-NOT transcription complex subunit 6

carbon catabolite repression 4 protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02905 CNOT6 Human Pre-designed siRNA Set A / Unkown
HY-RS02906 CNOT6L Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CNOT6 VGNC VGNC:61028
Bos taurus CNOT6 VGNC VGNC:27520
Macaca mulatta CNOT6 VGNC VGNC:71175
Mus musculus CNOT6 MGD MGI:2144529
Rattus norvegicus CNOT6 RGD RGD:1310783
Canis familiaris CNOT6 VGNC VGNC:39416