SERINC1 - serine incorporator 1 Gene

Homo sapiens

Also known as TDE2; TMS2; TDE1L; TMS-2

Gene ID: 57515 | Gene type: protein coding

About SERINC1

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:122,443,351-122,471,807 (from NCBI)

This gene has 1 transcript (splice variant), 219 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 241.4), adrenal (RPKM 145.5) and 25 other tissues.

Summary

Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in several processes, including phosphatidylserine metabolic process; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; and positive regulation of serine C-palmitoyltransferase activity. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]

SERINC1 Products(1)

mRNA	Protein	Name
NM_020755.4	NP_065806.1	serine incorporator 1 precursor

SERINC1 Protein Structure

Serinc

0
100
200
300
400
453 a.a.

Protein Preferred Names

Protein Names

serine incorporator 1

tumor differentially expressed protein 2

Related Diseases

Diseases

Alias

Spastic Paraplegia 50, Autosomal Recessive

Hereditary Spastic Paraplegia 50	SPG50
Ap-4 Deficiency Syndrome	Ap-4-Associated Hereditary Spastic Paraplegia
Adaptor Protein Complex 4 Deficiency	Cerebral Palsy, Spastic Quadriplegic, 3, Formerly
Cpsq3, Formerly	Autosomal Recessive Spastic Paraplegia 50
Cpsq3	Spastic Quadriplegic Cerebral Palsy 3
Ap-4 Deficiency	Ap-4-Associated Hsp
Paraplegia, Spastic, Autosomal Recessive, Type 50	Spastic Paraplegia-50, Autosomal Recessive

Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome	Duane'S Syndrome
Duane Syndrome	Isolated Duane Retraction Syndrome
Co-Contractive Retraction Syndrome	Duane Anomaly, Isolated
Ocular Retraction Syndrome	Drs
Durs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12690	SERINC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SERINC1	RGD	RGD:727843
Canis familiaris	SERINC1	VGNC	VGNC:46019
Macaca mulatta	SERINC1	VGNC	VGNC:77226
Felis catus	SERINC1	VGNC	VGNC:65017
Mus musculus	SERINC1	MGD	MGI:1926228

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