ISLR2 - immunoglobulin superfamily containing leucine rich repeat 2 Gene

Homo sapiens

Also known as LINX

Gene ID: 57611 | Gene type: protein coding

About ISLR2

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,100,318-74,141,826 (from NCBI)

This gene has 11 transcripts (splice variants), 100 orthologues and 3 paralogues. Biased expression in brain (RPKM 4.7), testis (RPKM 3.0) and 5 other tissues.

Summary

Predicted to be involved in positive regulation of axon extension. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Apr 2022]

ISLR2 Products(4)

mRNA	Protein	Name
NM_001130136.1	NP_001123608.1	immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor
NM_001130137.1	NP_001123609.1	immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor
NM_001130138.2	NP_001123610.1	immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor
NM_020851.3	NP_065902.1	immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor

ISLR2 Protein Structure

LRR_8

Ig_2

0
200
400
600
745 a.a.

Protein Preferred Names

Protein Names

immunoglobulin superfamily containing leucine-rich repeat protein 2

leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein

Related Diseases

Diseases

Alias

Melanotic Medulloblastoma

Medulloblastoma, Melanotic

Breast Angiosarcoma

Angiosarcoma Of The Breast	Hemangiosarcoma Of The Breast
Primary Angiosarcoma Of Breast

Breast Sarcoma

Sarcoma Of Breast

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06934	ISLR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ISLR2	MGD	MGI:2444277
Rattus norvegicus	ISLR2	RGD	RGD:6497037
Bos taurus	ISLR2	VGNC	VGNC:30299
Macaca mulatta	ISLR2	VGNC	VGNC:73682
Canis familiaris	ISLR2	VGNC	VGNC:59114
Felis catus	ISLR2	VGNC	VGNC:80947

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