2. Gene
  3. LRRN1 - leucine rich repeat neuronal 1 Gene

LRRN1 - leucine rich repeat neuronal 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NLRR1; NLRR-1; FIGLER3

Gene ID: 57633 | Gene type: protein coding

About LRRN1

Cytogenetic location: 3p26.2 Genomic coordinates (GRCh38): 3:3,799,431-3,849,834 (from NCBI)

This gene has 3 transcripts (splice variants), 196 orthologues and 25 paralogues. Biased expression in brain (RPKM 12.5), testis (RPKM 4.5) and 8 other tissues.

Summary

Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

LRRN1 Products(3)

mRNA Protein Name
NM_001324188.2 NP_001311117.1 leucine-rich repeat neuronal protein 1 precursor
NM_001324189.2 NP_001311118.1 leucine-rich repeat neuronal protein 1 precursor
NM_020873.7 NP_065924.3 leucine-rich repeat neuronal protein 1 precursor

LRRN1 Protein Structure

LRR_1

LRR_1: Leucine Rich Repeat (96 - 118)

LRR_8

LRR_8: Leucine rich repeat (120 - 177)

LRR_8

LRR_8: Leucine rich repeat (216 - 275)

LRR_8

LRR_8: Leucine rich repeat (312 - 373)

I-set

I-set: Immunoglobulin I-set domain (431 - 516)

  • 0
  • 200
  • 400
  • 600
  • 716 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat neuronal protein 1

fibronectin type III, immunoglobulin and leucine rich repeat domains 3

Related Diseases

Diseases Alias
Brittle Cornea Syndrome 1

Brittle Cornea Syndrome

Fragilitas Oculi With Joint Hyperextensibility

Dysgenesis Mesodermalis Corneae Et Sclerae

BCS1

Corneal Fragility, Keratoglobus, Blue Sclerae, Joint Hyperextensibility

Ehlers-Danlos Syndrome, Type Vib, Formerly

Eds6b, Formerly

Type Vib Ehlers-Danlos Syndrome

Eds Vib

Ehlers-Danlos Syndrome Type 6b

Corneal Fragility Keratoglobus Blue Sclerae Joint Hyperextensibility

Eds6b Formerly

Ehlers-Danlos Syndrome Type Vib Formerly

Ehlers-Danlos Syndrome Type 6

Cornea, Brittle, Syndrome

Cornea, Brittle, Syndrome, Type 1

Ehlers-Danlos Syndrome 6b
Corneal Dystrophy, Posterior Polymorphous, 1

Posterior Polymorphous Corneal Dystrophy

Ppcd

Maumenee Corneal Dystrophy

Posterior Polymorphous Corneal Dystrophy 1

PPCD1

Corneal Dystrophy, Hereditary Polymorphous Posterior

Corneal Endothelial Dystrophy 1, Autosomal Dominant

Schlichting Dystrophy

Ched1

Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly

Ched1, Formerly

Hereditary Polymorphus Posterior Corneal Dystrophy

Posterior Polymorphous Dystrophy

Hereditary Polymorphous Posterior Corneal Dystrophy

Dystrophy, Corneal, Posterior Polymorphous

Dystrophy, Corneal, Posterior Polymorphous, Type 1

Polymorphous Corneal Dystrophy

Corneal Endothelial Dystrophy 2
Malignant Inflammatory Fibrous Histiocytoma

Inflammatory Mfh

Xanthosarcoma
Differentiating Neuroblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07836 LRRN1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LRRN1 VGNC VGNC:74324
Mus musculus LRRN1 MGD MGI:106038
Felis catus LRRN1 VGNC VGNC:82360
Rattus norvegicus LRRN1 RGD RGD:1564145
Canis familiaris LRRN1 VGNC VGNC:42824
Bos taurus LRRN1 VGNC VGNC:31039
Others LRRN1 NCBI