2. Gene
  3. PLEKHA4 - pleckstrin homology domain containing A4 Gene

PLEKHA4 - pleckstrin homology domain containing A4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as PEPP1

Gene ID: 57664 | Gene type: protein coding

About PLEKHA4

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,837,097-48,868,617 (from NCBI)

This gene has 11 transcripts (splice variants), 164 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 7.2), endometrium (RPKM 6.0) and 24 other tissues.

Summary

This gene encodes a pleckstrin homology (PH) domain-containing protein. The PH domain is found near the N-terminus and contains a putative phosphatidylinositol 3, 4, 5-triphosphate-binding motif (PPBM). Elevated expression of this gene has been observed in some melanomas. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

PLEKHA4 Products(2)

mRNA Protein Name
NM_001161354.2 NP_001154826.1 pleckstrin homology domain-containing family A member 4 isoform 2
NM_020904.3 NP_065955.2 pleckstrin homology domain-containing family A member 4 isoform 1

PLEKHA4 Protein Structure

PH

PH: PH domain (56 - 152)

  • 0
  • 200
  • 400
  • 600
  • 779 a.a.
Protein Preferred Names Protein Names

pleckstrin homology domain-containing family A member 4

PH domain-containing family A member 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10681 PLEKHA4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PLEKHA4 VGNC VGNC:76027
Felis catus PLEKHA4 VGNC VGNC:64218
Bos taurus PLEKHA4 VGNC VGNC:33006
Mus musculus PLEKHA4 MGD MGI:1916467
Rattus norvegicus PLEKHA4 RGD RGD:735133
Canis familiaris PLEKHA4 VGNC VGNC:53751