2. Gene
  3. SCUBE2 - signal peptide, CUB domain and EGF like domain containing 2 Gene

SCUBE2 - signal peptide, CUB domain and EGF like domain containing 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CEGB1; CEGF1; CEGP1; scube/You

Gene ID: 57758 | Gene type: protein coding

About SCUBE2

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:9,019,476-9,091,599 (from NCBI)

This gene has 14 transcripts (splice variants), 209 orthologues and 2 paralogues. Broad expression in prostate (RPKM 8.1), urinary bladder (RPKM 7.3) and 20 other tissues.

Summary

Predicted to enable calcium ion binding activity; Hedgehog family protein binding activity; and lipid binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including positive regulation of chondrocyte proliferation; positive regulation of osteoblast differentiation; and positive regulation of smoothened signaling pathway. Predicted to be located in extracellular region. Predicted to be active in cell surface and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

SCUBE2 Products(4)

mRNA Protein Name
NM_001170690.3 NP_001164161.1 signal peptide, CUB and EGF-like domain-containing protein 2 isoform 2 precursor
NM_001330199.3 NP_001317128.1 signal peptide, CUB and EGF-like domain-containing protein 2 isoform 3 precursor
NM_001367977.2 NP_001354906.1 signal peptide, CUB and EGF-like domain-containing protein 2 isoform 4 precursor
NM_020974.4 NP_066025.2 signal peptide, CUB and EGF-like domain-containing protein 2 isoform 1 precursor

SCUBE2 Protein Structure

EGF_CA

EGF_CA: Calcium-binding EGF domain (45 - 84)

cEGF

cEGF: Complement Clr-like EGF-like (109 - 131)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (132 - 167)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (286 - 321)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (327 - 362)

EGF_CA

EGF_CA: Calcium-binding EGF domain (364 - 394)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (407 - 442)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (673 - 720)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (729 - 776)

CUB

CUB: CUB domain (781 - 890)

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  • 971 a.a.
Protein Preferred Names Protein Names

signal peptide, CUB and EGF-like domain-containing protein 2

Related Diseases

Diseases Alias
Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation

Intracranial Arteriovenous Malformation

Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To

Intracranial Arteriovenous Malformations

Bavm

Cerebral Arteriovenous Malformations

Intracranial Hemorrhage In Brain Cerebrovascular Malformations

Arteriovenous Malformation Of The Brain, Somatic

Intracranial Avm

Arteriovenous Malformations Cerebral
Central Nervous System Tuberculosis

Intracranial Tuberculoma

Tuberculoma Of Brain

Tuberculosis Of Meninges And Central Nervous System

Tuberculous Abscess Of Brain

Tuberculoma, Intracranial

Tuberculosis, Central Nervous System
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12572 SCUBE2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SCUBE2 RGD RGD:1563998
Felis catus SCUBE2 VGNC VGNC:64938
Canis familiaris SCUBE2 VGNC VGNC:45936
Bos taurus SCUBE2 VGNC VGNC:34372
Macaca mulatta SCUBE2 VGNC VGNC:77138
Mus musculus SCUBE2 MGD MGI:1928765