SLC4A5 - solute carrier family 4 member 5 Gene

Homo sapiens

Also known as NBC4; NBCe2

Gene ID: 57835 | Gene type: protein coding

About SLC4A5

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:74,216,242-74,343,416 (from NCBI)

This gene has 14 transcripts (splice variants), 279 orthologues and 9 paralogues. Broad expression in thyroid (RPKM 9.5), testis (RPKM 8.1) and 14 other tissues.

Summary

This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

SLC4A5 Products(3)

mRNA	Protein	Name
NM_001386136.1	NP_001373065.1	electrogenic sodium bicarbonate cotransporter 4 isoform e
NM_021196.3	NP_067019.3	electrogenic sodium bicarbonate cotransporter 4 isoform a
NM_133478.3	NP_597812.1	electrogenic sodium bicarbonate cotransporter 4 isoform c

SLC4A5 Protein Structure

Band_3_cyto

HCO3_cotransp

0
200
400
600
800
1040 a.a.

Protein Preferred Names

Protein Names

electrogenic sodium bicarbonate cotransporter 4

solute carrier family 4 (sodium bicarbonate cotransporter), member 5

Related Diseases

Diseases

Alias

Alstrom Syndrome

ALMS	Alström Syndrome
Alss	Alstrom-Hallgren Syndrome
Alstroem Syndrome

Intestinal Impaction

Corneal Dystrophy, Band-Shaped

Band Keratopathy

Band-Shaped Keratopathy

Complex Partial Epilepsy

Epilepsy, Complex Partial	Complex Partial Epileptic Seizure
Epilepsy, Psychomotor	Psychomotor Epilepsy

Corneal Dystrophy And Perceptive Deafness

Corneal Dystrophy-Perceptive Deafness Syndrome	CDPD
Harboyan Syndrome	Cdpd1
Corneal Dystrophy And Sensorineural Deafness	Corneal Endothelial Dystrophy And Perceptive Deafness
Corneal Dystrophy With Progressive Deafness	Congenital Corneal Dystrophy, Progressive Sensorineural Deafness
Corneal Dystrophy With Progressive Hearing Loss	Corneal Dystrophy-Perceptive Hearing Loss Syndrome
Dystrophy, Corneal, Endothelial, And Perceptive Deafness

Corneal Degeneration

Degenerative Corneal Opacity

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13271	SLC4A5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC4A5	MGD	MGI:2443220
Felis catus	SLC4A5	VGNC	VGNC:65390
Bos taurus	SLC4A5	VGNC	VGNC:34895
Rattus norvegicus	SLC4A5	RGD	RGD:1303009
Canis familiaris	SLC4A5	VGNC	VGNC:46435
Macaca mulatta	SLC4A5	VGNC	VGNC:106220

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