2. Gene
  3. RABGGTB - Rab geranylgeranyltransferase subunit beta Gene

RABGGTB - Rab geranylgeranyltransferase subunit beta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GGTB

Gene ID: 5876 | Gene type: protein coding

About RABGGTB

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:75,786,194-75,795,090 (from NCBI)

This gene has 14 transcripts (splice variants), 227 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 28.6), kidney (RPKM 27.1) and 25 other tissues.

Summary

This gene encodes the beta-subunit of the Enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013]

RABGGTB Products(1)

mRNA Protein Name
NM_004582.4 NP_004573.2 geranylgeranyl transferase type-2 subunit beta

RABGGTB Protein Structure

SQHop_cyclase_N

SQHop_cyclase_N: Squalene-hopene cyclase N-terminal domain (73 - 182)

Prenyltrans

Prenyltrans: Prenyltransferase and squalene oxidase repeat (213 - 253)

Prenyltrans

Prenyltrans: Prenyltransferase and squalene oxidase repeat (258 - 302)

  • 0
  • 100
  • 200
  • 300
  • 331 a.a.
Protein Preferred Names Protein Names

geranylgeranyl transferase type-2 subunit beta

GGTase-II-beta

Related Diseases

Diseases Alias
Choroideremia

CHM

Tcd

Progressive Tapetochoroidal Dystrophy

Choroidal Sclerosis

Tapetochoroidal Dystrophy, Progressive

Progressive Choroidal Atrophy

Tapetochoroidal Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11588 RABGGTB Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RABGGTB VGNC VGNC:76641
Mus musculus RABGGTB MGD MGI:99537
Canis familiaris RABGGTB VGNC VGNC:45304
Felis catus RABGGTB VGNC VGNC:69208
Bos taurus RABGGTB VGNC VGNC:33671
Rattus norvegicus RABGGTB RGD RGD:3530