2. Gene
  3. Erbb4 - erb-b2 receptor tyrosine kinase 4 Gene

Erbb4 - erb-b2 receptor tyrosine kinase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 59323 | Gene type: protein coding

About Erbb4

Primary_assembly 9: 69,531,481-70,596,595 reverse strand.mRatBN7.2:CM026982.1

This gene has 4 transcripts (splice variants), 227 orthologues, 54 paralogues and is associated with 44 phenotypes. Biased expression in Brain (RPKM 139.1), Kidney (RPKM 128.9) and 5 other tissues.

Summary

Predicted to enable several functions, including epidermal growth factor receptor binding activity; protein homodimerization activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including animal organ development; positive regulation of GABAergic synaptic transmission; and positive regulation of glucose import. Located in several cellular components, including caveola; postsynaptic density; and postsynaptic membrane. Colocalizes with inhibitory synapse. Used to study visual epilepsy. Biomarker of congestive heart failure; median neuropathy; radiculopathy; and schizophrenia. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Erbb4 Products(1)

mRNA Protein Name
NM_021687.2 NP_067719.2 receptor tyrosine-protein kinase erbB-4 precursor

Erbb4 Protein Structure

Recep_L_domain

Recep_L_domain: pfam01030 (54 - 166)

Furin-like

Furin-like: pfam00757 (185 - 331)

Recep_L_domain

Recep_L_domain: pfam01030 (357 - 477)

GF_recep_IV

GF_recep_IV: pfam14843 (501 - 633)

TM_ErbB4

TM_ErbB4: cd12092 (641 - 684)

PTKc_HER4

PTKc_HER4: cd05110 (709 - 1011)

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  • 1308 a.a.
Protein Preferred Names Protein Names

receptor tyrosine-protein kinase erbB-4

c-erbB-4

proto-oncogene-like protein c-ErbB-4

receptor tyrosine kinase

v-erb-a erythroblastic leukemia viral oncogene homolog 4

v-erb-b2 avian erythroblastic leukemia viral oncogene 4

Recombinant Erbb4 Proteins

Cat. No. Product Name Accession Purity
HY-P73036 HER4 Protein, Rat (HEK293, Fc) Q62956 (Q26-P651) ≥95%
HY-P73037 HER4 Protein, Rat (HEK293, His) Q62956 (Q26-P651) ≥95%

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13272 Dacomitinib 99.74% Yes
Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0793 AZ-5104 Inhibitor 99.70% Unkown
HY-18609 PD158780 Inhibitor 99.56% Unkown
HY-13427 Allitinib tosylate Inhibitor 99.83% Unkown
HY-103440 EGFR/ErbB-2/ErbB-4 inhibitor-3 Inhibitor 98.19% Unkown
HY-112420 EGFR/ErbB-2/ErbB-4 inhibitor-2 Inhibitor 99.69% Unkown
HY-103441 JNJ28871063 hydrochloride Inhibitor / Unkown
HY-13272S2 Dacomitinib-d10 dihydrochloride ≥95.0% Unkown
HY-RS04472 ERBB4 Human Pre-designed siRNA Set A / Unkown
HY-13272S3 Dacomitinib-d10 / Unkown
HY-B0793S1 AZ-5104-d2 Inhibitor / Unkown
HY-RS04473 Erbb4 Mouse Pre-designed siRNA Set A / Unkown
HY-RS04474 Erbb4 Rat Pre-designed siRNA Set A / Unkown
HY-15375 Allitinib Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Erbb4 NCBI NCBI:2066