TSKS - testis specific serine kinase substrate Gene

Homo sapiens

Also known as TSKS1; TSSKS; STK22S1; PPP1R161

Gene ID: 60385 | Gene type: protein coding

About TSKS

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,739,760-49,763,306 (from NCBI)

This gene has 3 transcripts (splice variants) and 101 orthologues. Restricted expression toward testis (RPKM 31.5).

Summary

This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular Cancer. The gene is localized to the region 19q13.3 among the related Ras viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. [provided by RefSeq, Jul 2008]

TSKS Products(1)

mRNA	Protein	Name
NM_021733.2	NP_068379.1	testis-specific serine kinase substrate

TSKS Protein Structure

TSKS

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592 a.a.

Protein Preferred Names

Protein Names

testis-specific serine kinase substrate

STK22 substrate 1

Related Diseases

Diseases

Alias

Testicular Cancer

Testis Cancer	Testicular Carcinoma
Testicular Neoplasms	Malignant Neoplasm Of Testis
Childhood Neoplasm Of The Testis	Neoplasm Of Testis
Pediatric Testicular Neoplasm	Testicular Tumor
Testis Neoplasm	Testicular Tumors
Testicular Neoplasm	Testicular Malignant Germ Cell Tumor
Childhood Testicular Neoplasm	Carcinoma Of The Testis
Cancer Of Testis	Malignant Neoplasm Of Testis, Nos
Malignant Neoplasm Of Testis, Unspecified	Malignant Tumour Of Testis
Testicle Cancer	Primary Malignant Neoplasm Of Testis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15151	TSKS Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TSKS	VGNC	VGNC:47906
Bos taurus	TSKS	VGNC	VGNC:36421
Rattus norvegicus	TSKS	RGD	RGD:727784
Felis catus	TSKS	VGNC	VGNC:66620
Macaca mulatta	TSKS	VGNC	VGNC:79868
Mus musculus	TSKS	MGD	MGI:1347560