2. Gene
  3. RNF4 - ring finger protein 4 Gene

RNF4 - ring finger protein 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SLX5; SNURF; RES4-26

Gene ID: 6047 | Gene type: protein coding

About RNF4

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,469,106-2,515,857 (from NCBI)

This gene has 21 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in lymph node (RPKM 20.6), testis (RPKM 19.4) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010]

RNF4 Products(3)

mRNA Protein Name
NM_001185009.3 NP_001171938.1 E3 ubiquitin-protein ligase RNF4 isoform 1
NM_001185010.3 NP_001171939.1 E3 ubiquitin-protein ligase RNF4 isoform 2
NM_002938.5 NP_002929.1 E3 ubiquitin-protein ligase RNF4 isoform 1

RNF4 Protein Structure

zf-RING_2

zf-RING_2: Ring finger domain (131 - 177)

  • 0
  • 100
  • 190 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF4

E3 ubiquitin ligase RNF4

Related Diseases

Diseases Alias
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-143346 CCW16 98.63% Unkown
HY-RS12090 RNF4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RNF4 VGNC VGNC:34065
Mus musculus RNF4 MGD MGI:1201691
Rattus norvegicus RNF4 RGD RGD:3583
Canis familiaris RNF4 VGNC VGNC:53203
Felis catus RNF4 VGNC VGNC:64702
Macaca mulatta RNF4 VGNC VGNC:76705
Others RNF4 NCBI