RNH1 - ribonuclease/angiogenin inhibitor 1 Gene

Homo sapiens

Also known as RAI; RNH

Gene ID: 6050 | Gene type: protein coding

About RNH1

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:494,515-507,242 (from NCBI)

This gene has 24 transcripts (splice variants), 1 gene allele, 126 orthologues and 4 paralogues. Ubiquitous expression in skin (RPKM 36.6), lung (RPKM 36.0) and 25 other tissues.

Summary

Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]

RNH1 Products(8)

mRNA	Protein	Name
NM_002939.4	NP_002930.2	ribonuclease inhibitor
NM_203383.2	NP_976317.1	ribonuclease inhibitor
NM_203384.2	NP_976318.1	ribonuclease inhibitor
NM_203385.2	NP_976319.1	ribonuclease inhibitor
NM_203386.3	NP_976320.1	ribonuclease inhibitor
NM_203387.3	NP_976321.1	ribonuclease inhibitor
NM_203388.3	NP_976322.1	ribonuclease inhibitor
NM_203389.3	NP_976323.1	ribonuclease inhibitor

RNH1 Protein Structure

LRR_6

0
100
200
300
400
461 a.a.

Protein Preferred Names

Protein Names

ribonuclease inhibitor

placental RNase inhibitor

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12100	RNH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RNH1	VGNC	VGNC:64709
Mus musculus	RNH1	MGD	MGI:1195456
Bos taurus	RNH1	VGNC	VGNC:106900
Canis familiaris	RNH1	VGNC	VGNC:45680
Rattus norvegicus	RNH1	RGD	RGD:621398
Others	RNH1	NCBI

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