RPL8 - ribosomal protein L8 Gene

Homo sapiens

Also known as L8

Gene ID: 6132 | Gene type: protein coding

About RPL8

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,789,769-144,792,390 (from NCBI)

This gene has 14 transcripts (splice variants), 233 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 817.1), colon (RPKM 466.9) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPL8 Products(4)

mRNA	Protein	Name
NM_000973.5	NP_000964.1	60S ribosomal protein L8
NM_001317771.2	NP_001304700.1	60S ribosomal protein L8
NM_001317782.2	NP_001304711.1	60S ribosomal protein L8
NM_033301.3	NP_150644.1	60S ribosomal protein L8

RPL8 Protein Structure

Ribosomal_L2

Ribosomal_L2_C

0
100
200
257 a.a.

Protein Preferred Names

Protein Names

60S ribosomal protein L8

large ribosomal subunit protein uL2

Related Diseases

Diseases

Alias

Spermatogenic Failure 2

SPGF2	Aspermiogenesis Factor
Asg

Spermatogenic Failure 1

Oligosynaptic Infertility	SPGF1
Oligochiasmatic Infertility	Oligochiasmic Infertility

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12205	RPL8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RPL8	RGD	RGD:619827
Macaca mulatta	RPL8	VGNC	VGNC:84110
Canis familiaris	RPL8	VGNC	VGNC:45720
Felis catus	RPL8	VGNC	VGNC:64740
Mus musculus	RPL8	MGD	MGI:1350927

Name
Email *

	Sorry, but the email address you supplied was invalid.