RTN1 - reticulon 1 Gene

Homo sapiens

Also known as NSP

Gene ID: 6252 | Gene type: protein coding

About RTN1

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:59,595,976-59,870,776 (from NCBI)

This gene has 8 transcripts (splice variants), 228 orthologues and 4 paralogues. Biased expression in brain (RPKM 96.0) and spleen (RPKM 6.9).

Summary

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and Cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]

RTN1 Products(3)

mRNA	Protein	Name
NM_001363702.1	NP_001350631.1	reticulon-1 isoform D
NM_021136.3	NP_066959.1	reticulon-1 isoform A
NM_206852.3	NP_996734.1	reticulon-1 isoform C

RTN1 Protein Structure

Reticulon

0
200
400
600
776 a.a.

Protein Preferred Names

Protein Names

reticulon-1

neuroendocrine-specific protein

Related Diseases

Diseases

Alias

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12329	RTN1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RTN1	VGNC	VGNC:64810
Canis familiaris	RTN1	VGNC	VGNC:51680
Mus musculus	RTN1	MGD	MGI:1933947
Bos taurus	RTN1	VGNC	VGNC:34203
Rattus norvegicus	RTN1	RGD	RGD:620986
Macaca mulatta	RTN1	VGNC	VGNC:84762