S100A9 - S100 calcium binding protein A9 Gene

Homo sapiens

Also known as MIF; NIF; P14; CAGB; CFAG; CGLB; L1AG; LIAG; MRP14; 60B8AG; MAC387; S100-A9

Gene ID: 6280 | Gene type: protein coding

About S100A9

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,357,854-153,361,023 (from NCBI)

This gene has 1 transcript (splice variant), 344 orthologues and 21 paralogues. Biased expression in bone marrow (RPKM 7440.5), esophagus (RPKM 5956.4) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of Casein Kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits Antifungal and Antibacterial activity. [provided by RefSeq, Nov 2014]

S100A9 Products(1)

mRNA	Protein	Name
NM_002965.4	NP_002956.1	protein S100-A9

S100A9 Protein Structure

S_100

0
100
114 a.a.

Protein Preferred Names

Protein Names

protein S100-A9

MRP-14

Recombinant S100A9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70532	S100A9 Protein, Human	P06702 (T2-P114)	≥95%
HY-P71076	S100A8-S100A9 Heterodimer Protein, Human (His)	P05109 (M1-E93)(S100A8) & P06702 (T2-P114) (S100A9)	≥95%
HY-P73670	S100A8-S100A9 Heterodimer Protein, Human (sf9, Flag-His)	P05109 (M1-E93)&P06702 (M1-P114)	≥95%
HY-P76587	S100A9 Protein, Human (sf9, His)	P06702 (M1-P114)	≥95%
HY-P70532A	S100A9 Protein, Human (His)	P06702 (T2-P114)	≥95%

Related Diseases

Diseases

Alias

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Juvenile Rheumatoid Arthritis

Juvenile Idiopathic Arthritis	Juvenile Chronic Polyarthritis
Monarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Arthritis
Still'S Disease	Systemic Juvenile Rheumatoid Arthritis
Juvenile Chronic Arthritis	Acute Juvenile Rheumatoid Arthritis
Pauciarticular Onset Juvenile Chronic Arthritis	Arthritis, Juvenile Rheumatoid
Jia	Jra
Juvenile Ra	Arthritis Juvenile Rheumatoid
Stills Disease	Juvenile Arthritis
Acute Polyarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Rheumatoid Arthritis
Rheumatoid Arthritis, Systemic Juvenile

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Erythema Elevatum Diutinum

Fibroma

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Psoriasis

Pouchitis

Appendicitis

Acute Appendicitis	Acute Appendicitis With Generalized Peritonitis
Acute Appendicitis Nos	Acute Appendicitis With Peritoneal Abscess
Appendiceal Inflammation	Appendicitis, Unqualified
Acute Appendix Inflammation	Acute Appendicitis With Diffuse Peritonitis Following Rupture Or Perforation
Acute Appendicitis With Free Peritonitis	Acute Appendicitis With Free Perforation To The Abdominal Cavity
Perforated Appendix With Generalised Peritonitis	Appendicitis With Perforation And Free Pus In The Peritoneal Cavity
Perforated Appendix With Localised Peritonitis	Acute Appendicitis With Contained Perforation To A Localised Abscess
Acute Appendicitis With Localised Peritonitis With Rupture Or Perforation	Acute Appendicitis With Localised Peritonitis Without Rupture Or Perforation
Acute Appendicitis With Perforation And Contained Peritonitis Into An Abscess	Appendicitis With Abscess
Appendicitis With Peritoneal Abscess	Ruptured Appendix Nos
Acute Appendicitis With No Perforation Or Abscess And No Visible Pus	Acute Appendicitis With No Specification If Perforated Or Not
Acute Appendicitis With Phlegmone

Renal Infectious Disease

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Vasculitis

Angiitis	Autoimmune Vasculitis
Systemic Vasculitis	Vasculitis, Autoimmune

Gout

Gouty Arthritis	Articular Gout
Gouty Arthropathy	Arthritis, Gouty
Arthritis Gouty	Idiopathic Gout
Idiopathic Gout, Unspecified Site	Gouty Bursitis
Uratic Arthritis	Gout Nos
Gouty	Gouty Diathesis

Lung Disease

Lung Diseases	Disorder Of Lung
Abnormality Of The Lung

Kawasaki Disease

Mucocutaneous Lymph Node Syndrome	Acute Febrile Mucocutaneous Lymph Node Syndrome
Kawasaki Syndrome	Kd
Infantile Polyarteritis	Kawasaki Disease, Susceptibility To
Acute Febrile Mcls	Kawasaki'S Disease
Mlns	KWD

Nodular Tenosynovitis

Synovioma, Benign	Benign Synovioma
Benign Tumor Of Synovium	Localized Giant Cell Tumor Of Tenosynovium
Giant Cell Tumor Of Tendon Sheath

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diverticulitis

Multicentric Reticulohistiocytosis

Lipoid Dermatoarthritis

Giant Cell Histiocytomatosis

Sexual Sadism

Sadism

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Spondylarthropathy

Spondylarthropathies

Congenital Epulis

Gingival Neoplasms	Congenital Epulides
Congenital Gingival Cell Tumor	Congenital Granular Cell Tumor
Neumann Tumor

Sarcoidosis 1

Sarcoidosis	Boeck Sarcoid
Besnier-Boeck-Schaumann Disease	SS1
Sarcoidosis, Susceptibility To, 1	Lymphogranulomatosis
Hodgkin Disease	Boeck'S Disease
Boeck'S Sarcoid	Schaumann'S Disease Or Syndrome
Hutchinson-Boeck Disease Or Syndrome

Omsk Hemorrhagic Fever

Ohf	Hemorrhagic Fever, Omsk
Ohf - [Omsk Haemorrhagic Fever]	Spring-Fall Haemorrhagic Fever

Congenital Granular Cell Tumor

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10528	Tasquinimod	Modulator	99.94%	Phase 3
HY-100442	Paquinimod	Inhibitor	99.91%	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10528S	Tasquinimod-d3	Modulator	99.34%	Unkown
HY-100442S1	Paquinimod-d5-1	Inhibitor	98.19%	Unkown
HY-RS12386	S100A9 Human Pre-designed siRNA Set A		/	Unkown
HY-100442S	Paquinimod-d5	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	S100A9	RGD	RGD:620267
Mus musculus	S100A9	MGD	MGI:1338947
Bos taurus	S100A9	VGNC	VGNC:34247
Macaca mulatta	S100A9	VGNC	VGNC:76961
Felis catus	S100A9	VGNC	VGNC:64843
Canis familiaris	S100A9	NCBI
Macaca fascicularis	S100A9	NCBI
Others	S100A9	NCBI

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