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  3. SARS1 - seryl-tRNA synthetase 1 Gene

SARS1 - seryl-tRNA synthetase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SARS; SERS; SERRS; NEDMAS

Gene ID: 6301 | Gene type: protein coding

About SARS1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,213,893-109,238,182 (from NCBI)

This gene has 6 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 44.0), brain (RPKM 25.3) and 25 other tissues.

Summary

This gene belongs to the class II amino-acyl tRNA family. The encoded Enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to Bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]

SARS1 Products(2)

mRNA Protein Name
NM_001330669.1 NP_001317598.1 serine--tRNA ligase, cytoplasmic isoform b
NM_006513.4 NP_006504.2 serine--tRNA ligase, cytoplasmic isoform a

SARS1 Protein Structure

Seryl_tRNA_N

Seryl_tRNA_N: Seryl-tRNA synthetase N-terminal domain (2 - 92)

tRNA-synt_2b

tRNA-synt_2b: tRNA synthetase class II core domain (G, H, P, S and T) (203 - 384)

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  • 514 a.a.
Protein Preferred Names Protein Names

serine--tRNA ligase, cytoplasmic

serine tRNA ligase 1, cytoplasmic

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Microcephaly, Ataxia, And Seizures

NEDMAS
Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation

Intracranial Arteriovenous Malformation

Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To

Intracranial Arteriovenous Malformations

Bavm

Cerebral Arteriovenous Malformations

Intracranial Hemorrhage In Brain Cerebrovascular Malformations

Arteriovenous Malformation Of The Brain, Somatic

Intracranial Avm

Arteriovenous Malformations Cerebral
Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid
Hyperuricemia

Blood Urate Raized

Uricacidemia
Joubert Syndrome 7

JBTS7

Cerebello-Oculo-Renal Syndrome 3

Cors3

Joubert Syndrome, Type 7
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1564A [Sar1, Ile8]-Angiotensin II TFA 99.70% Unkown
HY-P0205B Saralasin TFA Antagonist 99.65% Unkown
HY-P0205 Saralasin Antagonist / Unkown
HY-P0205A Saralasin acetate hydrate Antagonist / Unkown
HY-P1564 [Sar1, Ile8]-Angiotensin II / Unkown
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P4685 (Sar1,Ile4,8)-Angiotensin II Agonist 98.69% Unkown
HY-P3138 (Sar1)-Angiotensin II Agonist 99.31% Unkown
HY-RS12442 SAR1A Human Pre-designed siRNA Set A / Unkown
HY-RS12443 SAR1B Human Pre-designed siRNA Set A / Unkown
HY-RS12448 SARS1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SARS1 MGD MGI:102809
Bos taurus SARS1 VGNC VGNC:34291
Canis familiaris SARS1 VGNC VGNC:45869
Rattus norvegicus SARS1 RGD RGD:628813
Macaca mulatta SARS1 VGNC VGNC:100131