2. Gene
  3. BIK - BCL2 interacting killer Gene

BIK - BCL2 interacting killer Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BP4; NBK; BIP1

Gene ID: 638 | Gene type: protein coding

About BIK

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:43,110,750-43,129,712 (from NCBI)

This gene has 1 transcript (splice variant) and 52 orthologues. Biased expression in stomach (RPKM 6.4), colon (RPKM 5.6) and 13 other tissues.

Summary

The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, Bak, BAD and Bax, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]

BIK Products(1)

mRNA Protein Name
NM_001197.5 NP_001188.1 bcl-2-interacting killer

BIK Protein Structure

bcl-2I13

bcl-2I13: Bcl2-interacting killer, BH3-domain containing (1 - 159)

  • 0
  • 100
  • 160 a.a.
Protein Preferred Names Protein Names

bcl-2-interacting killer

BCL2-interacting killer (apoptosis-inducing)

Related Diseases

Diseases Alias
Hyperinsulinemic Hypoglycemia, Familial, 1

HHF1

Persistent Hyperinsulinemic Hypoglycemia Of Infancy

Familial Hyperinsulinemic Hypoglycemia 1

Congenital Hyperinsulinism

Phhi

Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency

Hypoglycemia, Hyperinsulinemic, Of Infancy

Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia

Nesidioblastosis Of Pancreas

Hyperinsulinism, Familial, With Pancreatic Nesidioblastosis

Hyperinsulinism, Congenital

Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency

Diazoxide-Resistant Focal Hyperinsulinism Due To Sur1 Deficiency

Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency, Diazoxide-Resistant Focal Form

Autosomal Recessive Hyperinsulinism Due To Sur1 Deficiency

Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency

Hypoglycemia, Hyperinsulinemic, Familial, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-50868 Bafetinib 99.77% Phase 2
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P5341 Bik BH3 / Unkown
HY-RS01503 BIK Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BIK RGD RGD:621547
Mus musculus BIK MGD MGI:1206591
Canis familiaris BIK VGNC VGNC:38457
Macaca mulatta BIK VGNC VGNC:107772
Others BIK NCBI