SDCBP - syndecan binding protein Gene

Homo sapiens

Also known as ST1; MDA9; SYCL; MDA-9; TACIP18

Gene ID: 6386 | Gene type: protein coding

About SDCBP

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:58,553,261-58,582,858 (from NCBI)

This gene has 13 transcripts (splice variants), 179 orthologues and 4 paralogues. Ubiquitous expression in placenta (RPKM 77.0), gall bladder (RPKM 73.7) and 25 other tissues.

Summary

The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the Cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017]

SDCBP Products(9)

mRNA	Protein	Name
NM_001007067.2	NP_001007068.1	syntenin-1 isoform 1
NM_001007068.2	NP_001007069.1	syntenin-1 isoform 2
NM_001007069.2	NP_001007070.1	syntenin-1 isoform 3
NM_001007070.2	NP_001007071.1	syntenin-1 isoform 3
NM_001330537.2	NP_001317466.1	syntenin-1 isoform 4
NM_001348339.2	NP_001335268.1	syntenin-1 isoform 5
NM_001348340.2	NP_001335269.1	syntenin-1 isoform 6
NM_001348341.2	NP_001335270.1	syntenin-1 isoform 7
NM_005625.4	NP_005616.2	syntenin-1 isoform 1

SDCBP Protein Structure

PDZ

0
100
200
298 a.a.

Protein Preferred Names

Protein Names

syntenin-1

melanoma differentiation associated protein-9

Recombinant SDCBP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71014	Syntenin-1 Protein, Human (C-His)	O00560 (S2-V298)	≥95%
HY-P71014A	Syntenin-1 Protein, Human (N-His)	NP_001007068.1 (M1-V298)	≥95%

Related Diseases

Diseases

Alias

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Deafness, Autosomal Dominant 33

DFNA33	Autosomal Dominant Nonsyndromic Deafness 33
Autosomal Dominant Deafness 33

Acoustic Neuroma

Neurofibromatosis Type 2	Vestibular Schwannoma
Acoustic Neurinoma	Bilateral Acoustic Neurofibromatosis
Nf2	Acoustic Neurilemoma
Cerebellopontine Angle Tumor	Neurofibromatosis Central Type
Neurofibromatosis Type Ii	Vestibular Neurilemmoma
Acoustic Tumor	Neurinoma Of The Acoustic Nerve
Acoustic Neurinoma Bilateral	Acoustic Schwannomas Bilateral
Banf	Central Neurofibromatosis
Familial Acoustic Neuromas	Neurofibromatosis 2
Neurofibromatosis Type 2 Merlin	Schwannoma, Acoustic, Bilateral
Neuroma Acoustic	Neuroma, Acoustic
Familial Acoustic Neuroma	Familial Vestibular Schwannoma
Neurofibromatosis, Central Type	Nf2 - [Neurofibromatosis Type 2]

Branchiootorenal Syndrome 2

BOR2	Bor Syndrome 2
Branchiootorenal Dysplasia 2	Branchio-Oto-Renal Dysplasia 2
Branchio-Oto-Renal Syndrome Type 2	Branchiootorenal Syndrome, Type 2

Small Cell Carcinoma

Small Cell Carcinoma, Intermediate Cell	Intermediate Cell Small Cell Carcinoma
Small Cell Carcinoma - Intermediate Cell	Small Cell Carcinoma Of Lung
Carcinoma, Small Cell

Pontiac Fever

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156247	IVMT-Rx-3	Inhibitor	/	Unkown
HY-RS12583	SDCBP Human Pre-designed siRNA Set A		/	Unkown
HY-RS12584	SDCBP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SDCBP	VGNC	VGNC:81695
Mus musculus	SDCBP	MGD	MGI:1337026
Macaca mulatta	SDCBP	VGNC	VGNC:77000
Bos taurus	SDCBP	VGNC	VGNC:34382
Rattus norvegicus	SDCBP	RGD	RGD:621497
Others	SDCBP	NCBI

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