2. Gene
  3. Pde10a - phosphodiesterase 10A Gene

Pde10a - phosphodiesterase 10A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Pde10a3

Gene ID: 63885 | Gene type: protein coding

About Pde10a

Primary_assembly 1: 51,770,132-52,216,563 reverse strand.mRatBN7.2:CM026974.1

This gene has 7 transcripts (splice variants), 207 orthologues, 20 paralogues and is associated with 4 phenotypes. Biased expression in Brain (RPKM 161.1), Adrenal (RPKM 82.4) and 6 other tissues.

Summary

Enables cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of cAMP-mediated signaling and negative regulation of cGMP-mediated signaling. Located in membrane and perikaryon. Orthologous to human PDE10A (phosphodiesterase 10A). [provided by Alliance of Genome Resources, Apr 2022]

Pde10a Products(4)

mRNA Protein Name
NM_001388510.1 NP_001375439.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 2
NM_022236.2 NP_071572.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 1
NM_001388509.1 NP_001375438.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 2
NM_001388511.1 NP_001375440.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3

Pde10a Protein Structure

GAF

GAF: pfam01590 (381 - 524)

GAF

GAF: smart00065 (557 - 712)

PDEase_I

PDEase_I: pfam00233 (804 - 1035)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1075 a.a.
Protein Preferred Names Protein Names

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

testis-specific phosphodiesterase PDE10A2

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-12472 Balipodect Inhibitor 98.91% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-50098A Mardepodect hydrochloride Inhibitor 95.10% Phase 2
Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50098 Mardepodect Inhibitor 99.69% Unkown
HY-14550 TP-10 Inhibitor 99.88% Unkown
HY-153093 MK-8189 Inhibitor 99.88% Unkown
HY-12913 AMG 579 Inhibitor 99.02% Unkown
HY-117604 THPP-1 Inhibitor 98.75% Unkown
HY-18078 PQ-10 Inhibitor 99.77% Unkown
HY-131973 PDE10A-IN-2 hydrochloride Inhibitor 98.43% Unkown
HY-112704 PDE5-IN-2 Inhibitor / Unkown
HY-10568 TC-E 5005 Inhibitor / Unkown
HY-123743 JNJ-42314415 Inhibitor / Unkown
HY-135848 N-Methylbenzamide Inhibitor 99.82% Unkown
HY-152838 Gemlapodect Inhibitor / Unkown
HY-158237 PDE10A-IN-3 Inhibitor / Unkown
HY-160111 PDM-042 Inhibitor / Unkown
HY-RS10199 PDE10A Human Pre-designed siRNA Set A / Unkown
HY-RS10200 Pde10a Mouse Pre-designed siRNA Set A / Unkown
HY-RS10201 Pde10a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde10a NCBI NCBI:10846