CHP2 - calcineurin like EF-hand protein 2 Gene

Homo sapiens

Gene ID: 63928 | Gene type: protein coding

About CHP2

This gene has 1 transcript (splice variant), 114 orthologues and 8 paralogues. Biased expression in duodenum (RPKM 110.6), small intestine (RPKM 92.6) and 2 other tissues.

Summary

This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with Calcineurin B and can bind to and stimulate the protein Phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013]

CHP2 Products(1)

mRNA	Protein	Name
NM_022097.4	NP_071380.1	calcineurin B homologous protein 2

CHP2 Protein Structure

EF-hand_6

EF-hand_7

EF-hand_5

0
100
196 a.a.

Protein Preferred Names

Protein Names

calcineurin B homologous protein 2

hepatocellular carcinoma antigen gene 520

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Macs Syndrome

Macrocephaly, Alopecia, Cutis Laxa, And Scoliosis	Mycobacterium Avium Complex Disease
Rin2 Syndrome	Mycobacterium Avium-Intracellulare Infection
Tall Forehead, Sparse Hair, Skin Hyperextensibility, And Scoliosis	Mycobacterium Avium Complex
Mycobacterium Avium Infection	Infection Due To Mycobacterium Intracellulare
Mac Disease	Macrocephaly-Alopecia-Cutis Laxa-Scoliosis Syndrome
Rin2 Deficiency	Tall Forehead-Sparse Hair-Skin Hyperextensibility-Scoliosis Syndrome
MACS	Macrocephaly Alopecia Cutis Laxa And Scoliosis Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02653	CHP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CHP2	VGNC	VGNC:54012
Mus musculus	CHP2	MGD	MGI:1917511
Macaca mulatta	CHP2	VGNC	VGNC:104688
Bos taurus	CHP2	VGNC	VGNC:27311
Rattus norvegicus	CHP2	RGD	RGD:727796
Felis catus	CHP2	VGNC	VGNC:107749