SRSF7 - serine and arginine rich splicing factor 7 Gene

Homo sapiens

Also known as 9G8; AAG3; SFRS7

Gene ID: 6432 | Gene type: protein coding

About SRSF7

Cytogenetic location: 2p22.1 Genomic coordinates (GRCh38): 2:38,743,599-38,751,494 (from NCBI)

This gene has 12 transcripts (splice variants), 232 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 57.8), lymph node (RPKM 43.5) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an N-terminal RNA recognition motif (RRM) for binding RNA and a C-terminal RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2018]

SRSF7 Products(3)

mRNA	Protein	Name
NM_001031684.3	NP_001026854.1	serine/arginine-rich splicing factor 7 isoform 1
NM_001195446.2	NP_001182375.1	serine/arginine-rich splicing factor 7 isoform 2
NM_001363802.1	NP_001350731.1	serine/arginine-rich splicing factor 7 isoform 3

SRSF7 Protein Structure

RRM_1

0
100
200
238 a.a.

Protein Preferred Names

Protein Names

serine/arginine-rich splicing factor 7

SR splicing factor 7

Related Diseases

Diseases

Alias

Allergic Bronchopulmonary Aspergillosis

Aspergillosis, Allergic Bronchopulmonary	Abpa
Allergic Bronchopulmonary Mycosis	Hinson-Pepys Disease
Pulmonary Aspergillus Disease	Allergic Aspergillosis
Aspergillosis Allergic Bronchopulmonary

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13798	SRSF7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SRSF7	VGNC	VGNC:77822
Felis catus	SRSF7	VGNC	VGNC:81226
Canis familiaris	SRSF7	VGNC	VGNC:46821
Rattus norvegicus	SRSF7	RGD	RGD:1307425
Mus musculus	SRSF7	MGD	MGI:1926232
Bos taurus	SRSF7	VGNC	VGNC:35303

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