2. Gene
  3. COP1 - COP1 E3 ubiquitin ligase Gene

COP1 - COP1 E3 ubiquitin ligase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FAP78; RFWD2; CFAP78; RNF200

Gene ID: 64326 | Gene type: protein coding

About COP1

Cytogenetic location: 1q25.1-q25.2 Genomic coordinates (GRCh38): 1:175,944,831-176,207,286 (from NCBI)

This gene has 11 transcripts (splice variants), 220 orthologues and 26 paralogues. Ubiquitous expression in testis (RPKM 5.8), colon (RPKM 4.2) and 25 other tissues.

Summary

Enables ubiquitin protein ligase activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to ionizing radiation. Part of Cul4A-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

COP1 Products(3)

mRNA Protein Name
NM_001001740.4 NP_001001740.1 E3 ubiquitin-protein ligase COP1 isoform b
NM_001286644.2 NP_001273573.1 E3 ubiquitin-protein ligase COP1 isoform c precursor
NM_022457.7 NP_071902.2 E3 ubiquitin-protein ligase COP1 isoform a

COP1 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (136 - 173)

WD40

WD40: WD domain, G-beta repeat (471 - 499)

WD40

WD40: WD domain, G-beta repeat (506 - 542)

WD40

WD40: WD domain, G-beta repeat (556 - 584)

WD40

WD40: WD domain, G-beta repeat (590 - 626)

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  • 200
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  • 731 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase COP1

E3 ubiquitin-protein ligase RFWD2

Related Diseases

Diseases Alias
Bn2 Diffuse Large B-Cell Lymphoma

Bn2 Dlbcl

Doid:0081064
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-157416 COP1-ATGL modulator 1 Modulator 99.31% Unkown
HY-RS03020 COP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta COP1 VGNC VGNC:106344
Mus musculus COP1 MGD MGI:1347046
Canis familiaris COP1 VGNC VGNC:53338
Felis catus COP1 VGNC VGNC:97388
Bos taurus COP1 VGNC VGNC:50041
Rattus norvegicus COP1 RGD RGD:1304773