2. Gene
  3. IKZF4 - IKAROS family zinc finger 4 Gene

IKZF4 - IKAROS family zinc finger 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EOS; ZNFN1A4

Gene ID: 64375 | Gene type: protein coding

About IKZF4

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:56,007,504-56,038,435 (from NCBI)

This gene has 13 transcripts (splice variants), 261 orthologues and 11 paralogues. Ubiquitous expression in adrenal (RPKM 4.5), testis (RPKM 3.7) and 25 other tissues.

Summary

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]

IKZF4 Products(5)

mRNA Protein Name
NM_001351089.2 NP_001338018.1 zinc finger protein Eos isoform a
NM_001351090.1 NP_001338019.1 zinc finger protein Eos isoform b
NM_001351091.2 NP_001338020.1 zinc finger protein Eos isoform c
NM_001351092.2 NP_001338021.1 zinc finger protein Eos isoform d
NM_022465.4 NP_071910.3 zinc finger protein Eos isoform a

IKZF4 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (174 - 197)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (201 - 224)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (248 - 271)

  • 0
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  • 400
  • 500
  • 585 a.a.
Protein Preferred Names Protein Names

zinc finger protein Eos

ikaros family zinc finger protein 4

Related Diseases

Diseases Alias
Alopecia Areata

Aa

Alopecia Celsi

Alopecia Circumscripta

Cazenave'S Vitiligo

Celsus' Vitiligo

Diffuse Alopecia

Jonston'S Alopecia

Marginal Alopecia

Pseudopelade

Circumscribed Alopecia

Alopecia Cicatrisata

Patchy Alopecia

Alopecia

Aa - [Alopecia Areata]

Pelade
Alopecia Universalis Congenita

Alopecia Universalis

ALUNC

Atrichia, Generalized

Au

Alopecia Areata Universalis

Atrichia Generalized
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06668 IKZF4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus IKZF4 MGD MGI:1343139
Felis catus IKZF4 VGNC VGNC:62901
Macaca mulatta IKZF4 VGNC VGNC:73588
Rattus norvegicus IKZF4 RGD RGD:2319157
Canis familiaris IKZF4 VGNC VGNC:41926
Bos taurus IKZF4 VGNC VGNC:30105