PIRT - phosphoinositide interacting regulator of transient receptor potential channels Gene

Homo sapiens

Gene ID: 644139 | Gene type: protein coding

About PIRT

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:10,822,470-10,838,087 (from NCBI)

This gene has 1 transcript (splice variant), 109 orthologues and 1 paralogue. Biased expression in adrenal (RPKM 1.6), brain (RPKM 1.3) and 7 other tissues.

Summary

Predicted to enable phosphatidylinositol bisphosphate binding activity and transmembrane transporter binding activity. Predicted to be involved in phosphatidylinositol-mediated signaling and positive regulation of cation channel activity. Predicted to act upstream of or within behavioral response to pain and response to heat. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PIRT Products(1)

mRNA	Protein	Name
NM_001101387.2	NP_001094857.1	phosphoinositide-interacting protein

PIRT Protein Structure

PIRT

0
100
137 a.a.

Protein Preferred Names

Protein Names

phosphoinositide-interacting protein

phosphoinositide-interacting regulator of TRPV1

Related Diseases

Diseases

Alias

Spastic Paraplegia 50, Autosomal Recessive

Hereditary Spastic Paraplegia 50	SPG50
Ap-4 Deficiency Syndrome	Ap-4-Associated Hereditary Spastic Paraplegia
Adaptor Protein Complex 4 Deficiency	Cerebral Palsy, Spastic Quadriplegic, 3, Formerly
Cpsq3, Formerly	Autosomal Recessive Spastic Paraplegia 50
Cpsq3	Spastic Quadriplegic Cerebral Palsy 3
Ap-4 Deficiency	Ap-4-Associated Hsp
Paraplegia, Spastic, Autosomal Recessive, Type 50	Spastic Paraplegia-50, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10572	PIRT Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PIRT	MGD	MGI:2443635
Bos taurus	PIRT	VGNC	VGNC:32916
Canis familiaris	PIRT	VGNC	VGNC:44580
Felis catus	PIRT	VGNC	VGNC:99318
Rattus norvegicus	PIRT	RGD	RGD:1565284