ALDH8A1 - aldehyde dehydrogenase 8 family member A1 Gene

Homo sapiens

Also known as ALDH12; DJ352A20.2

Gene ID: 64577 | Gene type: protein coding

About ALDH8A1

Cytogenetic location: 6q23.3 Genomic coordinates (GRCh38): 6:134,917,393-134,950,101 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues and 17 paralogues. Biased expression in liver (RPKM 60.7) and kidney (RPKM 37.6).

Summary

This gene encodes a member of the aldehyde dehydrogenase family of proteins. The encoded protein has been implicated in the synthesis of 9-cis-retinoic acid and in the breakdown of the amino acid tryptophan. This Enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. In addition, this Enzyme has been shown to catalyze the conversion of 2-aminomuconic semialdehyde to 2-aminomuconate in the kynurenine pathway of tryptophan catabolism. [provided by RefSeq, Jul 2018]

ALDH8A1 Products(3)

mRNA	Protein	Name
NM_001193480.2	NP_001180409.1	2-aminomuconic semialdehyde dehydrogenase isoform 3
NM_022568.4	NP_072090.1	2-aminomuconic semialdehyde dehydrogenase isoform 1
NM_170771.3	NP_739577.1	2-aminomuconic semialdehyde dehydrogenase isoform 2

ALDH8A1 Protein Structure

Aldedh

0
100
200
300
400
487 a.a.

Protein Preferred Names

Protein Names

2-aminomuconic semialdehyde dehydrogenase

aldehyde dehydrogenase 12

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00581	ALDH8A1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ALDH8A1	VGNC	VGNC:59739
Bos taurus	ALDH8A1	VGNC	VGNC:25819
Canis familiaris	ALDH8A1	VGNC	VGNC:37790
Macaca mulatta	ALDH8A1	VGNC	VGNC:69611
Mus musculus	ALDH8A1	MGD	MGI:2653900
Rattus norvegicus	ALDH8A1	RGD	RGD:1590218

Name
Email *

	Sorry, but the email address you supplied was invalid.