ANAPC1 - anaphase promoting complex subunit 1 Gene

Homo sapiens

Also known as APC1; MCPR; TSG24

Gene ID: 64682 | Gene type: protein coding

About ANAPC1

Cytogenetic location: 2q13 Genomic coordinates (GRCh38): 2:111,766,231-111,884,193 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 7.2), lymph node (RPKM 6.5) and 25 other tissues.

Summary

This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]

ANAPC1 Products(1)

mRNA	Protein	Name
NM_022662.4	NP_073153.1	anaphase-promoting complex subunit 1

ANAPC1 Protein Structure

ANAPC1

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1944 a.a.

Protein Preferred Names

Protein Names

anaphase-promoting complex subunit 1

anaphase-promoting complex 1 (meiotic checkpoint regulator)

Related Diseases

Diseases

Alias

Rothmund-Thomson Syndrome, Type 1

RTS1	Poikiloderma Atrophicans And Cataract
Rothmund-Thomson Syndrome Type 1	Poikiloderma Of Rothmund-Thomson Type 1
Rothmund-Thomson Syndrome 1

Rothmund-Thomson Syndrome, Type 2

Rothmund-Thomson Syndrome	Rts
RTS2	Poikiloderma Of Rothmund-Thomson
Rothmund-Thomson Syndrome Type 2	Congenital Poikiloderma
Poikiloderma Congenitale	Poikiloderma Atrophicans And Cataract
Poikiloderma Congenitale Of Rothmund-Thomson	Poikiloderma Of Rothmund-Thomson Type 2
Rothmund-Thomson Syndrome 2	Erythrokeratodermia Variabilis

Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy	Fuchs Endothelial Dystrophy
Fuchs Dystrophy	Fced
Fuchs' Corneal Dystrophy	Fuchs' Endothelial Corneal Dystrophy
Fuchs Atrophy	Fuchs Corneal Dystrophy
Endoepithelial Corneal Dystrophy	Fecd
Late Hereditary Endothelial Dystrophy	Corneal Dystrophy, Fuchs Endothelial
Dystrophy, Corneal, Fuchs Endothelial	Corneal Dystrophy, Fuchs' Endothelial, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00677	ANAPC1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ANAPC1	MGD	MGI:103097
Bos taurus	ANAPC1	VGNC	VGNC:25879
Canis familiaris	ANAPC1	VGNC	VGNC:37844
Rattus norvegicus	ANAPC1	RGD	RGD:1306629
Felis catus	ANAPC1	VGNC	VGNC:59774
Macaca mulatta	ANAPC1	VGNC	VGNC:69640

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