2. Gene
  3. DDX31 - DEAD-box helicase 31 Gene

DDX31 - DEAD-box helicase 31 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PPP1R25

Gene ID: 64794 | Gene type: protein coding

About DDX31

Cytogenetic location: 9q34.13 Genomic coordinates (GRCh38): 9:132,592,997-132,669,983 (from NCBI)

This gene has 5 transcripts (splice variants), 186 orthologues and 38 paralogues. Ubiquitous expression in thyroid (RPKM 4.3), ovary (RPKM 2.4) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2016]

DDX31 Products(7)

mRNA Protein Name
NM_001322340.2 NP_001309269.2 probable ATP-dependent RNA helicase DDX31 isoform 3
NM_001322341.2 NP_001309270.1 probable ATP-dependent RNA helicase DDX31 isoform 4
NM_001322342.1 NP_001309271.1 probable ATP-dependent RNA helicase DDX31 isoform 5
NM_001322343.1 NP_001309272.1 probable ATP-dependent RNA helicase DDX31 isoform 6
NM_001322344.2 NP_001309273.2 probable ATP-dependent RNA helicase DDX31 isoform 7
NM_022779.9 NP_073616.7 probable ATP-dependent RNA helicase DDX31 isoform 1
NM_138620.2 NP_619526.2 probable ATP-dependent RNA helicase DDX31 isoform 2

DDX31 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (255 - 431)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (553 - 602)

DUF4217

DUF4217: Domain of unknown function (DUF4217) (642 - 681)

  • 0
  • 200
  • 400
  • 600
  • 778 a.a.
Protein Preferred Names Protein Names

probable ATP-dependent RNA helicase DDX31

DEAD (Asp-Glu-Ala-Asp) box polypeptide 31

Related Diseases

Diseases Alias
Skin Sarcoma

Cutaneous Sarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03643 DDX31 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DDX31 MGD MGI:2682639
Felis catus DDX31 VGNC VGNC:61405
Rattus norvegicus DDX31 RGD RGD:1304895
Bos taurus DDX31 VGNC VGNC:27963
Macaca mulatta DDX31 VGNC VGNC:71631