SIPA1 - signal-induced proliferation-associated 1 Gene

Homo sapiens

Also known as SPA1

Gene ID: 6494 | Gene type: protein coding

About SIPA1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,638,101-65,650,912 (from NCBI)

This gene has 10 transcripts (splice variants), 175 orthologues and 6 paralogues. Broad expression in spleen (RPKM 30.1), lymph node (RPKM 17.9) and 24 other tissues.

Summary

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]

SIPA1 Products(2)

mRNA	Protein	Name
NM_006747.4	NP_006738.3	signal-induced proliferation-associated protein 1
NM_153253.30	NP_694985.29	signal-induced proliferation-associated protein 1

SIPA1 Protein Structure

Rap_GAP

PDZ

0
200
400
600
800
1042 a.a.

Protein Preferred Names

Protein Names

signal-induced proliferation-associated protein 1

GTPase-activating protein Spa-1

Related Diseases

Diseases

Alias

Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic	JMML
Leukemia, Juvenile Myelomonocytic, Somatic	Juvenile Chronic Myelomonocytic Leukemia
Juvenile Chronic Myelogenous Leukemia	Leukemia, Myelomonocytic, Juvenile
Juvenile Myelomonocytic Leukaemia Without Mention Of Remission

Myeloproliferative Neoplasm

Myeloproliferative Disorder	Chronic Myeloproliferative Disease
Myeloproliferative Neoplasms	Chronic Myeloproliferative Disorder
Cmpd	Cmpd, U
Chronic Myeloproliferative Disorders	Mpd
Mpn	Myeloproliferative Disorders
Myeloproliferative Disease	Campomelic Dysplasia

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS12928	SIPA1 Human Pre-designed siRNA Set A	/	Unkown
HY-RS12929	SIPA1L1 Human Pre-designed siRNA Set A	/	Unkown
HY-RS12930	SIPA1L2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS12931	SIPA1L3 Human Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SIPA1	MGD	MGI:107576
Canis familiaris	SIPA1	VGNC	VGNC:46179
Macaca mulatta	SIPA1	VGNC	VGNC:77218
Bos taurus	SIPA1	VGNC	VGNC:34627
Felis catus	SIPA1	VGNC	VGNC:65152
Rattus norvegicus	SIPA1	RGD	RGD:1303184

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