2. Gene
  3. INTS3 - integrator complex subunit 3 Gene

INTS3 - integrator complex subunit 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as INT3; SOSSA; SOSS-A; C1orf60; C1orf193

Gene ID: 65123 | Gene type: protein coding

About INTS3

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,728,050-153,774,808 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele and 200 orthologues. Ubiquitous expression in testis (RPKM 20.6), ovary (RPKM 17.9) and 25 other tissues.

Summary

The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016]

INTS3 Products(2)

mRNA Protein Name
NM_001324475.2 NP_001311404.1 integrator complex subunit 3
NM_023015.5 NP_075391.3 integrator complex subunit 3

INTS3 Protein Structure

Ints3

Ints3: Integrator complex subunit 3 (270 - 498)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1042 a.a.
Protein Preferred Names Protein Names

integrator complex subunit 3

SOSS complex subunit A

Related Diseases

Diseases Alias
Gand Syndrome

Mrd18

GAND

Mental Retardation, Autosomal Dominant 18

Autosomal Dominant Non-Syndromic Intellectual Disability 18

Autosomal Dominant Intellectual Developmental Disorder 18

Autosomal Dominant Mental Retardation 18
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06855 INTS3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus INTS3 VGNC VGNC:62944
Bos taurus INTS3 VGNC VGNC:30229
Macaca mulatta INTS3 VGNC VGNC:73659
Mus musculus INTS3 MGD MGI:2140050
Canis familiaris INTS3 VGNC VGNC:42052
Rattus norvegicus INTS3 RGD RGD:1304593