SLC10A2 - solute carrier family 10 member 2 Gene

Homo sapiens

Also known as ASBT; IBAT; ISBT; PBAM; NTCP2; PBAM1

Gene ID: 6555 | Gene type: protein coding

About SLC10A2

Cytogenetic location: 13q33.1 Genomic coordinates (GRCh38): 13:103,043,998-103,066,417 (from NCBI)

This gene has 1 transcript (splice variant), 213 orthologues, 5 paralogues and is associated with 2 phenotypes. Biased expression in small intestine (RPKM 25.8), duodenum (RPKM 11.2) and 1 other tissue.

Summary

This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of Cholesterol metabolism, so this protein is also critical for Cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with Other Diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010]

SLC10A2 Products(1)

mRNA	Protein	Name
NM_000452.3	NP_000443.2	ileal sodium/bile acid cotransporter

SLC10A2 Protein Structure

SBF

0
100
200
300
348 a.a.

Protein Preferred Names

Protein Names

ileal sodium/bile acid cotransporter

Na(+)-dependent ileal bile acid transporter	Na+/taurocholate cotransporting polypeptide 2
ileal apical sodium-dependent bile acid transporter	ileal bile acid transporter
ileal sodium-dependent bile acid transporter	sodium/taurocholate cotransporting polypeptide, ileal
solute carrier family 10 (sodium/bile acid cotransporter family), member 2	solute carrier family 10 (sodium/bile acid cotransporter), member 2

Related Diseases

Diseases

Alias

Cholestasis, Progressive Familial Intrahepatic, 5

PFIC5	Progressive Familial Intrahepatic Cholestasis 5
Nr1h4 Deficiency	Progressive Familial Intrahepatic Cholestasis Type 5
Cholestasis, Intrahepatic, Familial, Progressive, Type 5

Intrahepatic Cholestasis Of Pregnancy

Recurrent Intrahepatic Cholestasis Of Pregnancy	Gravidic Intrahepatic Cholestasis
Pregnancy-Related Cholestasis	Icp
Pregnancy Related Cholestasis	Cholestasis, Intrahepatic Of Pregnancy
Familial Intrahepatic Cholestasis Of Pregnancy	Familial Recurrent Intrahepatic Cholestasis Of Pregnancy
Ricp	Obstetric Cholestasis

Bile Acid Malabsorption, Primary, 1

Bile Acid Malabsorption, Primary	PBAM
PBAM1	Primary Bile Acid Malabsorption

Cholestasis, Benign Recurrent Intrahepatic, 1

Benign Recurrent Intrahepatic Cholestasis	BRIC1
Summerskill Syndrome	Bric
Summerskill-Walshe-Tygstrup Syndrome	Cholestasis, Benign Recurrent Intrahepatic
Benign Recurrent Intrahepatic Cholestasis 1	Benign Recurrent Intrahepatic Cholestasis Type 1
Bric Type 1	Low Gamma-Gt Familial Intrahepatic Cholestasis
Recurrent Familial Intrahepatic Cholestasis	Cholestasis, Benign Recurrent Intrahepatic 1
Mild Atp8b1 Deficiency	Recurrent Familial Intrahepatic Cholestasis 1
Abcb11-Related Intrahepatic Cholestasis	Atp8b1-Related Intrahepatic Cholestasis
Cholestasis, Intrahepatic, Recurrent, Benign, Type 1	Progressive Intrahepatic Cholestasis
Cholestasis, Progressive Familial Intrahepatic 3	Bric - [Benign Recurrent Intrahepatic Cholestasis]

Cholestasis, Progressive Familial Intrahepatic, 2

PFIC2	Cholestasis, Progressive Familial Intrahepatic 2
Progressive Familial Intrahepatic Cholestasis Type 2	Progressive Familial Intrahepatic Cholestasis 2
Bsep Deficiency	Recurrent Familial Intrahepatic Cholestasis 2
Benign Recurrent Intrahepatic Cholestasis 2	Severe Abcb11 Deficiency
Bric2	Cholestasis, Benign Recurrent Intrahepatic 2
Mild Abcb11 Deficiency	Cholestasis, Intrahepatic, Familial, Progressive, Type 2

Congenital Diarrhea

Cholestasis, Progressive Familial Intrahepatic, 4

PFIC4	Progressive Familial Intrahepatic Cholestasis 4
Cholestasis, Progressive Familial Intrahepatic 4	Tjp2 Deficit
Progressive Familial Intrahepatic Cholestasis-4	3-Beta-Hydroxy-Delta-5-C27-Steroid Oxidoreductase Deficiency
Progressive Familial Intrahepatic Cholestasis Type 4	Cholestasis, Intrahepatic, Familial, Progressive, Type 4
Bile Acid Synthesis Defect, Congenital, 1

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Hyperlipoproteinemia, Type Iv

Hyperlipoproteinemia Type Iv	Carbohydrate-Inducible Hyperlipemia
Endogenous Hyperlipidaemia	Familial Hypertriglyceridemia
Fredrickson Type Iv Hyperlipoproteinemia	Fredrickson Type Iv Lipidaemia
Fredrickson Type Iv Lipidemia	Vldl Hyperlipoproteinemia
Hyperlipoproteinemia Type 4	Carbohydrate Inducible Hyperlipemia
Familial Type Iv Hyperlipoproteinemia	Familial Hyperlipoproteinemia Type Iv

Sclerosing Cholangitis

Fibrosing Cholangitis	Cholangitis, Sclerosing
Primary Sclerosing Cholangitis

Hypertriglyceridemia 1

Hypertriglyceridemia	Hypertriglyceridemia, Familial
Hypertriglyceridemia, Susceptibility To	HYTG1
FHTR	Hypertriglyceridemias Familial

Pericholangitis

Biliary Tract Disease

Biliary Tract Diseases

Biliary Tract Abnormality

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Cholestasis

Obstruction Of Bile Duct	Bile Duct Obstruction
Bile Occlusion	Extrahepatic Biliary Obstruction
Extrahepatic Bile Duct Obstruction	Bile Stasis
Biliary Stasis	Obstructive Hyperbilirubinemia
Obstructed Jaundice	Bile Duct Obstructed
Bile Ductal Obstruction	Biliary Duct Obstruction
Obstructed Bile Ductal	Obstructed Biliary Duct
Obstructed Biliary Ductal	Jaundice Regurgitation
Obstructive Jaundice	Cholestatic Jaundice
Cholestatic Jaundice Syndrome

Bilirubin Metabolic Disorder

Hyperbilirubinemia	Hereditary Hyperbilirubinemia
Hyperbilirubinemia, Hereditary	Hyperbilirubinaemia

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Chylomicron Retention Disease

CMRD	Anderson Disease
Lipid Transport Defect Of Intestine	Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells
Andd	Anderson Syndrome
Crd	Andersons Disease
Malabsorption Syndrome

Cholestasis, Benign Recurrent Intrahepatic, 2

BRIC2	Benign Recurrent Intrahepatic Cholestasis 2
Benign Recurrent Intrahepatic Cholestasis Type 2	Bric Type 2
Cholestasis, Intrahepatic, Recurrent, Benign, Type 2	Cholestasis, Benign Recurrent Intrahepatic 2

Bile Duct Disease

Bile Duct Diseases	Bile Duct Disorder
Disorder Of Bile Duct

Functional Diarrhea

Functional Diarrhoea

Cholestasis, Progressive Familial Intrahepatic, 1

PFIC1	Byler Disease
Cholestasis, Progressive Familial Intrahepatic 1	Progressive Familial Intrahepatic Cholestasis 1
Progressive Familial Intrahepatic Cholestasis Type 1	Fic1 Deficiency
Byler'S Disease	Cholestasis, Fatal Intrahepatic
Progressive Familial Intrahepatic Cholestasis	Severe Atp8b1 Deficiency
Fatal Intrahepatic Cholestasis	Cholestasis, Intrahepatic, Familial, Progressive, Type 1
Progressive Intrahepatic Cholestasis	Cholestasis, Progressive Familial Intrahepatic 3

Hypercholesterolemia, Familial, 1

Hypercholesterolemia	FHCL1
Fhc	Fh
Hyperlipoproteinemia, Type Ii	Hyperlipoproteinemia, Type Iia
Hyper-Low-Density-Lipoproteinemia	Hypercholesterolemic Xanthomatosis, Familial
Ldl Receptor Disorder	Hypercholesterolemia, Susceptibility To
Hypercholesterolemia, Familial, Modifier Of	Hypercholesterolemia, Familial, Due To Ldlr Defect, Modifier Of
Ldl Cholesterol Level Qtl2	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial, Type 1	High Cholesterol
Increased Cholesterol	Low-Density-Lipoid-Type Hyperlipoproteinemia
Pure Hypercholesterolaemia	Ldl - [Low Density Lipoprotein} Hyperlipoproteinemia
Group A Hyperlipidaemia	Pure Hypercholesterinaemia
Cholesterolaemia	Essential Cholesterolaemia
Essential Hypercholesterolaemia	Group A Hyperlipemia
Increased Low Density Lipoprotein	Low-Density-Lipoprotein-Type
Low-Density-Lipoprotein-Type Hyperlipoproteinemia

Hepatitis D

Delta Hepatitis	Hepatitis Delta
Hdv	Hepatitis D Virus
Hepatitis D Infection

Progressive Familial Intrahepatic Cholestasis

Abcb4-Related Intrahepatic Cholestasis	Cholestasis, Progressive Familial Intrahepatic
Pfic	Byler Disease
Abcb11-Related Intrahepatic Cholestasis	Atp8b1-Related Intrahepatic Cholestasis
Bsep Deficiency	Byler Disease
Byler Syndrome	Fic1 Deficiency
Low Γ-Gt Familial Intrahepatic Cholestasis	Mdr3 Deficiency
Pfic	Cholestasis, Intrahepatic, Familial, Progressive
Pfic - [Progressive Familial Intrahepatic Cholestasis]

Extrahepatic Cholestasis

Cholestasis, Extrahepatic	Extrahepatic Biliary Stasis
Extrahepatic Obstructive Biliary Disease	Cholestasis Extrahepatic

Cholestasis, Progressive Familial Intrahepatic, 3

PFIC3	Cholestasis, Progressive Familial Intrahepatic 3
Mdr3 Deficiency	Progressive Familial Intrahepatic Cholestasis Type 3
Progressive Familial Intrahepatic Cholestasis 3	Progressive Familial Intrahepatic Cholestasis With Elevated Serum Gamma-Glutamyltransferase
Cholestasis, Progressive Familial Intrahepatic, With Elevated Serum Gamma-Glutamyltransferase	Progressive Familial Intrahepatic Cholestasis With Elevated Serum Gama-Glutamyltransferase
Cholestasis, Intrahepatic, Familial, Progressive, Type 3

Biliary Atresia

Congenital Biliary Atresia	Isolated Biliary Atresia
Isolated Atresia Of Bile Ducts	Non-Syndromic Biliary Atresia
Atresia Of Bile Duct	Biliary Atresia, Congenital
Atresia Of Bile Ducts	Bile Duct Atresia
Congenital Bile Duct Atresia	Ba - [Biliary Atresia]
Impervious Bile Duct	Atresia Of Common Duct
Biliary Duct Atresia	Bile Ductal Atresia
Cystic Duct Atresia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS12986	SLC10A2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS12987	Slc10a2 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS12988	Slc10a2 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC10A2	VGNC	VGNC:53832
Rattus norvegicus	SLC10A2	RGD	RGD:3682
Mus musculus	SLC10A2	MGD	MGI:1201406
Canis familiaris	SLC10A2	VGNC	VGNC:46212
Felis catus	SLC10A2	VGNC	VGNC:65181
Macaca mulatta	SLC10A2	VGNC	VGNC:77381

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