SIGLEC1 - sialic acid binding Ig like lectin 1 Gene

Homo sapiens

Also known as SN; CD169; SIGLEC-1

Gene ID: 6614 | Gene type: protein coding

About SIGLEC1

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,686,970-3,712,600 (from NCBI)

This gene has 2 transcripts (splice variants), 135 orthologues and 16 paralogues. Broad expression in placenta (RPKM 8.2), spleen (RPKM 6.4) and 20 other tissues.

Summary

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and Bacterial and viral infections has been shown to enhance SARS-CoV-2 Infection. [provided by RefSeq, Dec 2021]

SIGLEC1 Products(2)

mRNA	Protein	Name
NM_001367089.1	NP_001354018.1	sialoadhesin isoform 2 precursor
NM_023068.4	NP_075556.1	sialoadhesin isoform 1 precursor

SIGLEC1 Protein Structure

V-set

C2-set_2

Ig_2

I-set

Ig_2

I-set

Ig_2

0
300
600
900
1200
1500
1709 a.a.

Protein Preferred Names

Protein Names

sialoadhesin

sialic acid binding Ig-like lectin 1, sialoadhesin

Recombinant SIGLEC1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78743	Siglec-1/CD169 Protein, Human (HEK293, His)	Q9BZZ2 (S20-Q1641)	≥95%

Related Diseases

Diseases

Alias

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Heart Block, Congenital

Congenital Heart Block	Heart Block Congenital
Congenital Atrioventricular Block

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12897	SIGLEC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SIGLEC1	VGNC	VGNC:34617
Rattus norvegicus	SIGLEC1	RGD	RGD:1311953
Macaca mulatta	SIGLEC1	VGNC	VGNC:77220
Felis catus	SIGLEC1	VGNC	VGNC:65141
Mus musculus	SIGLEC1	MGD	MGI:1921304
Canis familiaris	SIGLEC1	VGNC	VGNC:46168
Macaca fascicularis	SIGLEC1	NCBI
Others	SIGLEC1	NCBI

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