SOX1 - SRY-box transcription factor 1 Gene

Homo sapiens

Gene ID: 6656 | Gene type: protein coding

About SOX1

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:112,067,149-112,071,706 (from NCBI)

This gene has 1 transcript (splice variant), 193 orthologues and 20 paralogues.

Summary

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. [provided by RefSeq, Jul 2008]

SOX1 Products(1)

mRNA	Protein	Name
NM_005986.3	NP_005977.2	transcription factor SOX-1

SOX1 Protein Structure

HMG_box

SOXp

0
100
200
300
391 a.a.

Protein Preferred Names

Protein Names

transcription factor SOX-1

SRY (sex determining region Y)-box 1

Related Diseases

Diseases

Alias

Lambert-Eaton Myasthenic Syndrome

Lambert-Eaton Syndrome	Eaton-Lambert Syndrome
Lems	Lambert Eaton Myasthenic Syndrome
Eaton Lambert Syndrome	Lambert Eaton Syndrome
Myasthenic Syndrome Of Lambert-Eaton	Myasthenic-Myopathic Syndrome Of Lambert-Eaton
Lems - [Lambert-Eaton Myasthenic Syndrome]

Bilateral Hypoactive Labyrinth

Hypoactive Bilateral Labyrinthine Dysfunction

Hypoactive Labyrinth, Bilateral

Inner Ear Disease

Labyrinthine Dysfunction	Diseases Of Inner Ear
Labyrinthine Disease	Abnormality Of The Inner Ear
Labyrinth Diseases	Labyrinthine Disorder
Nonfunctioning Labyrinth	Labyrinthine Loss Of Function
Labyrinthine Syndrome	Labyrinthine Disorder Nos

Paraneoplastic Polyneuropathy

Neuromuscular Junction Disease

Neuromuscular Junction Diseases

Autoimmune Disease Of Peripheral Nervous System

Limbic Encephalitis

Autoimmune Epilepsy

Retinitis Pigmentosa 50

RP50	Retinitis Pigmentosa, Concentric
Retinitis Pigmentosa-50	Retinitis Pigmentosa Concentric

Germ Cell And Embryonal Cancer

Germ Cell And Embryonal Neoplasm

Postinfectious Encephalitis

Postinfective Encephalitis

Secondary Encephalitis

Cataract 34, Multiple Types

Cataract, Autosomal Recessive Congenital 3	Cataract 34 Multiple Types
CTRCT34	Catc3
Cataract 34, Multiple Types, With Or Without Microcornea	Autosomal Recessive Congenital Cataract 3
Cataract 34 Multiple Types With Or Without Microcornea	Cataract, Multiple Types, Type 34

Germ Cell Cancer

Malignant Germ Cell Tumor	Neoplasms, Germ Cell And Embryonal
Germ Cell Neoplasm	Germ Cell Tumour
Malignant Tumor Of The Germ Cell	Neoplasms Germ Cell
Malignant Germ Cell Neoplasm

Neuromuscular Disease

Neuromuscular Diseases	Neuromuscular Disorders
Neuromuscular Disorder

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133028	CKI-7 free base	Inhibitor	99.34%	Unkown
HY-RS13582	SOX1 Human Pre-designed siRNA Set A		/	Unkown
HY-W011109	CKI-7	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SOX1	RGD	RGD:6487636
Bos taurus	SOX1	VGNC	VGNC:35140
Mus musculus	SOX1	MGD	MGI:98357
Canis familiaris	SOX1	VGNC	VGNC:57497

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