2. Gene
  3. BOK - BCL2 family apoptosis regulator BOK Gene

BOK - BCL2 family apoptosis regulator BOK Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BOKL; BCL2L9

Gene ID: 666 | Gene type: protein coding

About BOK

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,551,393-241,574,131 (from NCBI)

This gene has 2 transcripts (splice variants), 265 orthologues and 8 paralogues. Broad expression in fat (RPKM 69.1), liver (RPKM 18.4) and 16 other tissues.

Summary

The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces Apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011]

BOK Products(1)

mRNA Protein Name
NM_032515.5 NP_115904.1 bcl-2-related ovarian killer protein

BOK Protein Structure

Bcl-2

Bcl-2: Apoptosis regulator proteins, Bcl-2 family (70 - 171)

  • 0
  • 100
  • 200
  • 212 a.a.
Protein Preferred Names Protein Names

bcl-2-related ovarian killer protein

BCL2 related ovarian killer

Related Diseases

Diseases Alias
Retinitis Pigmentosa 71

RP71

Retinitis Pigmentosa, Type 71
Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01570 BOK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus BOK VGNC VGNC:60146
Bos taurus BOK VGNC VGNC:26538
Rattus norvegicus BOK RGD RGD:70984
Mus musculus BOK MGD MGI:1858494
Macaca mulatta BOK VGNC VGNC:104511
Others BOK NCBI