SRPK1 - SRSF protein kinase 1 Gene

Homo sapiens

Also known as SFRSK1

Gene ID: 6732 | Gene type: protein coding

About SRPK1

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,832,966-35,921,098 (from NCBI)

This gene has 13 transcripts (splice variants), 217 orthologues and 19 paralogues. Broad expression in testis (RPKM 31.4), bone marrow (RPKM 17.2) and 25 other tissues.

Summary

This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]

SRPK1 Products(1)

mRNA	Protein	Name
NM_003137.5	NP_003128.3	SRSF protein kinase 1

SRPK1 Protein Structure

Pkinase

0
200
400
600
655 a.a.

Protein Preferred Names

Protein Names

SRSF protein kinase 1

SFRS protein kinase 1

Recombinant SRPK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76088	SRPK1 Protein, Human (sf9, His-GST)	Q96SB4-2 (E2-S655)	≥95%

Related Diseases

Diseases

Alias

Denys-Drash Syndrome

Drash Syndrome	DDS
Nephropathy, Wilms Tumor, And Genital Anomalies	Wilms Tumor And Pseudohermaphroditism
Wilms Tumor And Pseudo- Or True Hermaphroditism	Nephropathy Associated With Male Pseudohermaphroditism And Wilms' Tumor
Pseudohermaphroditism, Nephron Disorder And Wilms' Tumor	Wilms Tumor-Dsd Syndrome
Wilms Tumor-Disorder Of Sex Development Syndrome

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117661	SPHINX31	Inhibitor	99.13%	Unkown
HY-13949	SRPIN340	Inhibitor	99.97%	Unkown
HY-116856	SRPKIN-1	Inhibitor	98.02%	Unkown
HY-148518	MSC-1186	Inhibitor	99.42%	Unkown
HY-114653	SRPIN803	Inhibitor	99.17%	Unkown
HY-132126	SPHINX	Inhibitor	99.87%	Unkown
HY-113831	CLK1/2-IN-3	Inhibitor	/	Unkown
HY-160586	Srpk1-IN-1	Inhibitor	/	Unkown
HY-160587	Antiangiogenic agent 5	Inhibitor	/	Unkown
HY-RS13777	SRPK1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SRPK1	RGD	RGD:1308272
Bos taurus	SRPK1	VGNC	VGNC:54238
Canis familiaris	SRPK1	VGNC	VGNC:54365
Felis catus	SRPK1	VGNC	VGNC:65687
Macaca mulatta	SRPK1	VGNC	VGNC:103870
Mus musculus	SRPK1	MGD	MGI:106908

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