RO60 - Ro60, Y RNA binding protein Gene

Homo sapiens

Also known as SSA2; RORNP; TROVE2

Gene ID: 6738 | Gene type: protein coding

About RO60

Cytogenetic location: 1q31.2 Genomic coordinates (GRCh38): 1:193,059,612-193,091,777 (from NCBI)

This gene has 12 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in brain (RPKM 6.6), prostate (RPKM 5.8) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in cellular response to interferon-alpha and regulation of gene expression. Located in cytosol and nucleoplasm. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]

RO60 Products(6)

mRNA	Protein	Name
NM_001042369.2	NP_001035828.1	RNA-binding protein RO60 isoform 1
NM_001042370.2	NP_001035829.2	RNA-binding protein RO60 isoform 3
NM_001173524.2	NP_001166995.1	RNA-binding protein RO60 isoform 2
NM_001173525.1	NP_001166996.1	RNA-binding protein RO60 isoform 4
NM_001331020.2	NP_001317949.1	RNA-binding protein RO60 isoform 5
NM_004600.5	NP_004591.2	RNA-binding protein RO60 isoform 2

RO60 Protein Structure

TROVE

DUF2201

0
100
200
300
400
500
538 a.a.

Protein Preferred Names

Protein Names

RNA-binding protein RO60

60 kDa ribonucleoprotein Ro

Related Diseases

Diseases

Alias

Sjogren Syndrome

Sicca Syndrome	Sjogren'S Syndrome
Sjögren Syndrome	Sjogren-Gougerot Syndrome
Keratoconjunctivitis Sicca	Sjögren'S Syndrome
Xerodermosteosis	Dacryosialoadenopathia Atrophicans
Gougerot-Houwer-Sjogren Syndrome	Gougerot-Sjogren Syndrome
Keratoconjunctivitis Sicca-Xerostomia	Secreto-Inhibitor-Xerodermostenosis
Primary Sjogren Syndrome	Primary Sjogren-Gougerot Syndrome
Sjogrens Syndrome Primary	Sjogrens Syndrome
Dry Eye Syndromes

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Heart Block, Congenital

Congenital Heart Block	Heart Block Congenital
Congenital Atrioventricular Block

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Xerophthalmia

Conjunctival Xerosis

Systemic Scleroderma

Scleroderma	Progressive Systemic Sclerosis
Systemic Sclerosis	Scleroderma, Systemic
Scleroderma Syndrome	Dermatosclerosis
Familial Progressive Scleroderma	Progressive Scleroderma
Scleroderma Disease	Scleroderma, Localized
Diffuse Scleroderma	Scleroderma, Familial Progressive

Autoimmune Disease Of Exocrine System

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

Second-Degree Atrioventricular Block

Second-Degree Heart Block	Second Degree Atrioventricular Block
Second Degree Atrioventricular Heart Block	Second Degree Heart Block
Incomplete Atrioventricular Block, Second Degree Nos	Second-Degree Block, Type 1 And 2
Atrioventricular Block, Type 1 And 2	Second Degree Incomplete Atrioventricular Block
Av - [Atrioventricular] Block 2nd

Endocardial Fibroelastosis

Endomyocardial Fibroelastosis	Elastomyofibrosis
EFE	Efe - [Endocardial Fibroelastosis]
Primary Endocardial Fibroelastosis	Fibroelastosis Cordis
Fetal Endocarditis	Fibroelastosis
Congenital Endocardial Fibroelastosis	Congenital Valvular Endocarditis

Libman-Sacks Endocarditis

Libmann-Sachs, Endocarditis In Systemic Lupus Erythematosus

Keratoconjunctivitis Sicca

Kcs	Dry Eye Syndromes
Keratitis Sicca	Xerophthalmia

Antisynthetase Syndrome

As Syndrome

Anti-Jo1 Syndrome

Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous

Atrioventricular Block

Av Block

Neonatal Myasthenia Gravis

Myasthenia Gravis, Neonatal

Lacrimal Apparatus Disease

Lacrimal Apparatus Diseases

Sialadenitis

Sialoadenitis	Adenitis, Salivary Gland
Salivary Gland Inflammation	Salivary Gland Adenitis
Sialitis	Inflammation Of Salivary Gland
Inflammation Of Salivary Duct Or Gland	Salivary Glandular Adenitis
Sialoangiitis	Sialoangitis
Sialodochitis

Dry Eye Syndrome

Dry Eye Syndromes	Dry Eye Disease
Tear Film Insufficiency	Xerophthalmia

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Childhood Type Dermatomyositis

Juvenile Dermatomyositis	Juvenile Dm
Childhood Dermatomyositis	Amyopathic Dermatomyositis
Adm	Dermatomyositis Sine Myositis
Dermatomyositis, Childhood Type

Chromosomal Deletion Syndrome

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123838	Ro60-0175	Agonist	99.98%	Unkown
HY-103140	Ro60-0175 fumarate	Agonist	99.47%	Unkown
HY-RS12109	RO60 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RO60	VGNC	VGNC:36379
Rattus norvegicus	RO60	RGD	RGD:1305083
Macaca mulatta	RO60	VGNC	VGNC:100063
Mus musculus	RO60	MGD	MGI:106652
Felis catus	RO60	VGNC	VGNC:64713
Canis familiaris	RO60	VGNC	VGNC:47864

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