SSX1 - SSX family member 1 Gene

Homo sapiens

Also known as SSRC; CT5.1

Gene ID: 6756 | Gene type: protein coding

About SSX1

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,255,392-48,267,444 (from NCBI)

This gene has 1 transcript (splice variant), 105 orthologues, 7 paralogues and is associated with 70 phenotypes. Restricted expression toward testis (RPKM 3.9).

Summary

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in Cancer patients, and are potentially useful targets in Cancer vaccine-based immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2013]

SSX1 Products(2)

mRNA	Protein	Name
NM_001278691.2	NP_001265620.1	protein SSX1
NM_005635.4	NP_005626.1	protein SSX1

SSX1 Protein Structure

SSXRD

0
100
188 a.a.

Protein Preferred Names

Protein Names

protein SSX1

cancer/testis antigen 5.1

Related Diseases

Diseases

Alias

Sarcoma, Synovial

Synovial Sarcoma	Synovialosarcoma
Synovial Cell Sarcoma	Sarcoma Synovial

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Biphasic Synovial Sarcoma

Synovial Sarcoma, Biphasic

Biphasic Sarcoma Of Synovium

Spindle Cell Synovial Sarcoma

Synovial Sarcoma With Spindle Cell Components	Synovial Sarcoma, Monophasic Fibrous
Synovial Sarcoma, Spindle Cell

Epithelioid Cell Synovial Sarcoma

Synovial Sarcoma, Epithelioid Cell

Epithelioid Synovial Sarcoma

Monophasic Synovial Sarcoma

Monophasic Sarcoma Of Synovium

Tibial Adamantinoma

Tibial Adamantinoma Morphology

Adamantinoma Of Long Bones

Long Bone Adamantinoma

Synovium Cancer

Malignant Tumor Of Synovium

Synovial Neoplasm

Lung Sarcoma

Pulmonary Sarcoma

Spermatic Cord Cancer

Malignant Tumor Of Spermatic Cord	Malignant Tumor Of The Spermatic Cord
Spermatic Cord Ca	Malignant Neoplasm Of Spermatic Cord

Extraskeletal Mesenchymal Chondrosarcoma

Mesenchymal Extraosseous Chondrosarcoma

Synovium Neoplasm

Synovial Neoplasm

Tumor Of Synovium

Adult Cystic Nephroma

Multilocular Cystic Nephroma, Mixed Epithelial Stromal Tumour And Renal Epithelial Stromal Tumour

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Cellular Schwannoma

Cellular Neurinoma

Spindle Cell Sarcoma

Sarcoma	Sarcoma Spindle Cell
Sarcoma, Spindle Cell	Sarcoma - Category

Heart Sarcoma

Cardiac Sarcoma

Sarcoma Of Heart

Bone Angioendothelial Sarcoma

Osseous Hemangiosarcoma

Bone Angiosarcoma

Mediastinal Mesenchymal Tumor

Mediastinal Mesenchymal Tumour	Soft Tissue Tumor Of Mediastinum
Soft Tissue Tumour Of Mediastinum

Cellular Myxoid Liposarcoma

Round Cell Liposarcoma

Extraosseous Osteosarcoma

Extraskeletal Osteosarcoma

Extraskeletal Osteogenic Sarcoma

Hemangiopericytoma, Malignant

Hemangiopericytoma	Haemangiopericytic Meningioma
Malignant Hemangiopericytoma	Solitary Fibrous Tumor

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma	Liposarcoma, Myxoid
Mrcls	Myxoliposarcoma
MXLIPO	Liposarcoma Myxoid
Liposarcoma

Juxtacortical Chondroma

Periosteal Chondroma

Pleomorphic Liposarcoma

Pls	Liposarcoma Pleomorphic
Liposarcoma, Pleomorphic

Kidney Sarcoma

Renal Sarcoma

Sarcoma Of Kidney

Extraosseous Chondrosarcoma

Extraskeletal Myxoid Chondrosarcoma

Dedifferentiated Liposarcoma

Ddls	Liposarcoma Dedifferentiated
Liposarcoma, Dedifferentiated

Thymus Sarcomatoid Carcinoma

Thymic Carcinosarcoma

Thymic Sarcomatoid Carcinoma

Myxofibrosarcoma

Fibromyxosarcoma	Fibromyxoid Sarcoma
Myxoid Malignant Fibrous Histiocytoma	Dermatofibrosarcoma Protuberans, Myxoid

Sarcomatoid Mesothelioma

Malignant Fibrous Mesothelioma

Spindled Mesothelioma

Alveolar Soft Part Sarcoma

ASPS	Alveolar Soft-Part Sarcoma
Sarcoma, Alveolar Soft Part	Alveolar Soft Tissue Sarcoma
Sarcoma Alveolar Soft Part	Adult Alveolar Soft-Part Sarcoma
Childhood Alveolar Soft-Part Sarcoma

Kidney Fibrosarcoma

Fibrosarcoma Of The Kidney

Dermatofibrosarcoma Protuberans

DFSP	Dermatofibrosarcoma
Giant Cell Fibroblastoma	Metastatic Dermatofibrosarcoma Protuberans
Familial Dermatofibrosarcoma Protuberans	Darier-Ferrand Tumor
Darier-Hoffmann Tumor

Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma	Emc
Myxoid Extraosseous Chondrosarcoma

Rhabdomyosarcoma

Well-Differentiated Liposarcoma

Atypical Lipomatous Tumor	Atypical Lipoma
Alt	Wdls
Liposarcoma, Well Differentiated	Pleomorphic Lipoma

Desmoplastic Small Round Cell Tumor

Dsrct	Desmoplastic Small Round-Cell Tumor
Desmoplastic Small Round-Cell Neoplasm

Muscle Cancer

Myosarcoma	Malignant Neoplasm Of Muscle
Malignant Tumor Of Muscle	Malignant Tumor Of The Muscle
Muscle Neoplasms	Myomatous Neoplasm

Skeletal Muscle Cancer

Malignant Tumor Of Skeletal Muscle

Skeletal Muscle Neoplasm

Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma	Rhabdomyosarcoma, Alveolar
Rhabdomyosarcoma Alveolar	RMS2
Rmsa	Rhabdomyosarcoma 2, Alveolar
Alveolar Childhood Rhabdomyosarcoma	Arms
Rhabdomyosarcoma, Type 2

Kidney Clear Cell Sarcoma

Clear Cell Sarcoma Of Kidney	Childhood Kidney Clear Cell Sarcoma
Renal Clear Cell Sarcoma	Ccsk
Clear Cell Sarcoma Of The Kidney

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone