SYT4 - synaptotagmin 4 Gene

Homo sapiens

Also known as HsT1192

Gene ID: 6860 | Gene type: protein coding

About SYT4

Cytogenetic location: 18q12.3 Genomic coordinates (GRCh38): 18:43,267,892-43,277,490 (from NCBI)

This gene has 8 transcripts (splice variants), 204 orthologues and 31 paralogues. Biased expression in brain (RPKM 34.8), adrenal (RPKM 10.3) and 1 other tissue.

Summary

Predicted to enable several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in negative regulation of Catecholamine secretion and positive regulation of dendrite extension. Predicted to be located in several cellular components, including microvesicle; perinuclear region of cytoplasm; and secretory vesicle. Predicted to be active in several cellular components, including axon; exocytic vesicle; and glutamatergic synapse. Predicted to be integral component of neuronal dense core vesicle membrane. [provided by Alliance of Genome Resources, Apr 2022]

SYT4 Products(1)

mRNA	Protein	Name
NM_020783.4	NP_065834.1	synaptotagmin-4

SYT4 Protein Structure

0
100
200
300
400
425 a.a.

Protein Preferred Names

Protein Names

synaptotagmin-4

synaptotagmin IV

Related Diseases

Diseases

Alias

Pontocerebellar Hypoplasia, Type 2e

Pontocerebellar Hypoplasia Type 2	Pontocerebellar Hypoplasia Type 2e
Pch2	PCH2E
Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy	Pontocerebellar Hypoplasia 2e
Pcca2	Progressive Cerebello-Cerebral Atrophy Type 2
Doid:0112328	Hypoplasia, Pontocerebellar, Type 2e
Pontocerebellar Hypoplasia, Type 2d	Pontocerebellar Hypoplasia Type 2a

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14116	SYT4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SYT4	VGNC	VGNC:78076
Felis catus	SYT4	VGNC	VGNC:80495
Rattus norvegicus	SYT4	RGD	RGD:68397
Canis familiaris	SYT4	VGNC	VGNC:47047
Bos taurus	SYT4	VGNC	VGNC:35543
Mus musculus	SYT4	MGD	MGI:101759

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