TACR2 - tachykinin receptor 2 Gene

Homo sapiens

Also known as SKR; NK2R; NKNAR; TAC2R

Gene ID: 6865 | Gene type: protein coding

About TACR2

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:69,403,903-69,416,918 (from NCBI)

This gene has 2 transcripts (splice variants), 200 orthologues and 33 paralogues. Biased expression in esophagus (RPKM 8.8), endometrium (RPKM 7.3) and 9 other tissues.

Summary

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]

TACR2 Products(1)

mRNA	Protein	Name
NM_001057.3	NP_001048.2	substance-K receptor

TACR2 Protein Structure

7tm_1

0
100
200
300
398 a.a.

Protein Preferred Names

Protein Names

substance-K receptor

NK-2 receptor	NK-2R
neurokinin 2 receptor	neurokinin A receptor
neurokinin B receptor	seven transmembrane helix receptor

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Occupational Asthma

Capillary Malformations, Congenital

Familial Multiple Nevi Flammei	Nevi Flammei, Familial Multiple
CMC	Port-Wine Stain
Capillary Malformations	Cmal
Familial Multiple Port-Wine Stains	Capillary Malformation
Capillary Malformations, Congenital, 1, Somatic, Mosaic	Congenital Capillary Malformations
Port-Wine Stain Familial Multiple	Hereditary Capillary Malformations
Capillary Malformations, Hereditary	Capillary Malformations, Congenital, Type 1, Somatic, Mosaic
Strawberry Nevus Of Skin	Naevus Flammeus

Posterior Cerebral Artery Infarction

Infarction, Posterior Cerebral Artery

Baritosis

Deposition Of Barium In The Lungs

Inhalation Of Barytes

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Environmental Induced Asthma

Irritant Asthma

Constipation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14146	TACR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14147	Tacr2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14148	Tacr2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TACR2	VGNC	VGNC:78084
Bos taurus	TACR2	VGNC	VGNC:35561
Rattus norvegicus	TACR2	RGD	RGD:3812
Canis familiaris	TACR2	VGNC	VGNC:47067
Mus musculus	TACR2	MGD	MGI:98477
Felis catus	TACR2	VGNC	VGNC:65921

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