TGFB1I1 - transforming growth factor beta 1 induced transcript 1 Gene

Homo sapiens

Also known as HIC5; ARA55; HIC-5; TSC-5

Gene ID: 7041 | Gene type: protein coding

About TGFB1I1

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:31,472,152-31,477,960 (from NCBI)

This gene has 17 transcripts (splice variants), 187 orthologues and 2 paralogues. Broad expression in endometrium (RPKM 51.3), prostate (RPKM 29.5) and 20 other tissues.

Summary

This gene encodes a coactivator of the Androgen Receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate Androgen Receptor activity and may have a role to play in the treatment of prostate Cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

TGFB1I1 Products(3)

mRNA	Protein	Name
NM_001042454.3	NP_001035919.1	transforming growth factor beta-1-induced transcript 1 protein isoform 1
NM_001164719.1	NP_001158191.1	transforming growth factor beta-1-induced transcript 1 protein isoform 2
NM_015927.5	NP_057011.2	transforming growth factor beta-1-induced transcript 1 protein isoform 2

TGFB1I1 Protein Structure

Paxillin

LIM

0
100
200
300
400
461 a.a.

Protein Preferred Names

Protein Names

transforming growth factor beta-1-induced transcript 1 protein

androgen receptor coactivator 55 kDa protein

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14438	TGFB1I1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TGFB1I1	VGNC	VGNC:47308
Macaca mulatta	TGFB1I1	VGNC	VGNC:78333
Rattus norvegicus	TGFB1I1	RGD	RGD:620173
Felis catus	TGFB1I1	VGNC	VGNC:66132
Bos taurus	TGFB1I1	VGNC	VGNC:35801
Mus musculus	TGFB1I1	MGD	MGI:102784

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