2. Gene
  3. Pak4 - p21 (RAC1) activated kinase 4 Gene

Pak4 - p21 (RAC1) activated kinase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as mKIAA1142; 5730488L07Rik

Gene ID: 70584 | Gene type: protein coding

About Pak4

Chromosome 7: 28,258,244-28,297,610 reverse strand.GRCm39:CM001000.3

This gene has 4 transcripts (splice variants), 162 orthologues, 35 paralogues and is associated with 25 phenotypes. Ubiquitous expression in colon adult (RPKM 4.7), duodenum adult (RPKM 33.4) and 25 other tissues.

Summary

Enables protein kinase activity. Acts upstream of or within cellular response to organic cyclic compound and dendritic spine development. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PAK4 (p21 (RAC1) activated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Pak4 Products(1)

mRNA Protein Name
NM_027470.3 NP_081746.1 serine/threonine-protein kinase PAK 4

Pak4 Protein Structure

CRIB_PAK_like

CRIB_PAK_like: cd01093 (9 - 47)

PKc_like

PKc_like: cl21453 (301 - 592)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 593 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 4

PAK-4

p21 protein (Cdc42/Rac)-activated kinase 4

p21-activated kinase 4

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12793 Padnarsertib Inhibitor 99.86% Phase 2
HY-13007 PF-3758309 Inhibitor 99.84% Phase 1
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19538 FRAX1036 Inhibitor 98.88% Unkown
HY-125035 LCH-7749944 Inhibitor 99.36% Unkown
HY-13007B PF-3758309 dihydrochloride Inhibitor / Unkown
HY-13007A PF-3758309 hydrochloride Inhibitor / Unkown
HY-146681 PAK1-IN-1 Inhibitor / Unkown
HY-130628 PAK4-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pak4 NCBI NCBI:10298